The role of Fibrinogen-like proteins in Cancer

Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the carboxyl terminus. Recent investigations illustrated that two members of FREP family, fibrinogen-like protein-1 (FGL1) and fibrinogen-like protein-2 (FGL2), play crucial roles in cancer by regulating the...

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Detalles Bibliográficos
Autores principales: Yu, Jing, Li, Jing, Shen, Jing, Du, Fukuan, Wu, Xu, Li, Mingxing, Chen, Yu, Cho, Chi Hin, Li, Xiaobing, Xiao, Zhangang, Zhao, Yueshui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040309/
https://www.ncbi.nlm.nih.gov/pubmed/33867830
http://dx.doi.org/10.7150/ijbs.56748
Descripción
Sumario:Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the carboxyl terminus. Recent investigations illustrated that two members of FREP family, fibrinogen-like protein-1 (FGL1) and fibrinogen-like protein-2 (FGL2), play crucial roles in cancer by regulating the proliferation, invasion, and migration of tumor cells, or regulating the functions of immune cells in tumor microenvironment. Meanwhile, they are potential targets for medical intervention of tumor development. In this review, we discussed the structure, and the roles of FGL1 and FGL2 in tumors, especially the roles in regulating immune cell functions.

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