The role of Fibrinogen-like proteins in Cancer

Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the carboxyl terminus. Recent investigations illustrated that two members of FREP family, fibrinogen-like protein-1 (FGL1) and fibrinogen-like protein-2 (FGL2), play crucial roles in cancer by regulating the...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Jing, Li, Jing, Shen, Jing, Du, Fukuan, Wu, Xu, Li, Mingxing, Chen, Yu, Cho, Chi Hin, Li, Xiaobing, Xiao, Zhangang, Zhao, Yueshui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040309/
https://www.ncbi.nlm.nih.gov/pubmed/33867830
http://dx.doi.org/10.7150/ijbs.56748
_version_ 1783677760523206656
author Yu, Jing
Li, Jing
Shen, Jing
Du, Fukuan
Wu, Xu
Li, Mingxing
Chen, Yu
Cho, Chi Hin
Li, Xiaobing
Xiao, Zhangang
Zhao, Yueshui
author_facet Yu, Jing
Li, Jing
Shen, Jing
Du, Fukuan
Wu, Xu
Li, Mingxing
Chen, Yu
Cho, Chi Hin
Li, Xiaobing
Xiao, Zhangang
Zhao, Yueshui
author_sort Yu, Jing
collection PubMed
description Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the carboxyl terminus. Recent investigations illustrated that two members of FREP family, fibrinogen-like protein-1 (FGL1) and fibrinogen-like protein-2 (FGL2), play crucial roles in cancer by regulating the proliferation, invasion, and migration of tumor cells, or regulating the functions of immune cells in tumor microenvironment. Meanwhile, they are potential targets for medical intervention of tumor development. In this review, we discussed the structure, and the roles of FGL1 and FGL2 in tumors, especially the roles in regulating immune cell functions.
format Online
Article
Text
id pubmed-8040309
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-80403092021-04-16 The role of Fibrinogen-like proteins in Cancer Yu, Jing Li, Jing Shen, Jing Du, Fukuan Wu, Xu Li, Mingxing Chen, Yu Cho, Chi Hin Li, Xiaobing Xiao, Zhangang Zhao, Yueshui Int J Biol Sci Review Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the carboxyl terminus. Recent investigations illustrated that two members of FREP family, fibrinogen-like protein-1 (FGL1) and fibrinogen-like protein-2 (FGL2), play crucial roles in cancer by regulating the proliferation, invasion, and migration of tumor cells, or regulating the functions of immune cells in tumor microenvironment. Meanwhile, they are potential targets for medical intervention of tumor development. In this review, we discussed the structure, and the roles of FGL1 and FGL2 in tumors, especially the roles in regulating immune cell functions. Ivyspring International Publisher 2021-03-08 /pmc/articles/PMC8040309/ /pubmed/33867830 http://dx.doi.org/10.7150/ijbs.56748 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Yu, Jing
Li, Jing
Shen, Jing
Du, Fukuan
Wu, Xu
Li, Mingxing
Chen, Yu
Cho, Chi Hin
Li, Xiaobing
Xiao, Zhangang
Zhao, Yueshui
The role of Fibrinogen-like proteins in Cancer
title The role of Fibrinogen-like proteins in Cancer
title_full The role of Fibrinogen-like proteins in Cancer
title_fullStr The role of Fibrinogen-like proteins in Cancer
title_full_unstemmed The role of Fibrinogen-like proteins in Cancer
title_short The role of Fibrinogen-like proteins in Cancer
title_sort role of fibrinogen-like proteins in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040309/
https://www.ncbi.nlm.nih.gov/pubmed/33867830
http://dx.doi.org/10.7150/ijbs.56748
work_keys_str_mv AT yujing theroleoffibrinogenlikeproteinsincancer
AT lijing theroleoffibrinogenlikeproteinsincancer
AT shenjing theroleoffibrinogenlikeproteinsincancer
AT dufukuan theroleoffibrinogenlikeproteinsincancer
AT wuxu theroleoffibrinogenlikeproteinsincancer
AT limingxing theroleoffibrinogenlikeproteinsincancer
AT chenyu theroleoffibrinogenlikeproteinsincancer
AT chochihin theroleoffibrinogenlikeproteinsincancer
AT lixiaobing theroleoffibrinogenlikeproteinsincancer
AT xiaozhangang theroleoffibrinogenlikeproteinsincancer
AT zhaoyueshui theroleoffibrinogenlikeproteinsincancer
AT yujing roleoffibrinogenlikeproteinsincancer
AT lijing roleoffibrinogenlikeproteinsincancer
AT shenjing roleoffibrinogenlikeproteinsincancer
AT dufukuan roleoffibrinogenlikeproteinsincancer
AT wuxu roleoffibrinogenlikeproteinsincancer
AT limingxing roleoffibrinogenlikeproteinsincancer
AT chenyu roleoffibrinogenlikeproteinsincancer
AT chochihin roleoffibrinogenlikeproteinsincancer
AT lixiaobing roleoffibrinogenlikeproteinsincancer
AT xiaozhangang roleoffibrinogenlikeproteinsincancer
AT zhaoyueshui roleoffibrinogenlikeproteinsincancer

Ejemplares similares