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Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process
Chronic venous insufficiency (CVI) is one of the most common vascular pathologies worldwide. One of the risk factors for the development of CVI is aging, which is why it is related to senile changes. The main trigger of the changes that occur in the venous walls in CVI is blood flow reflux, which pr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040408/ https://www.ncbi.nlm.nih.gov/pubmed/33850461 http://dx.doi.org/10.7150/ijms.54052 |
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author | Ortega, Miguel A Asúnsolo, Ángel Pekarek, Leonel Alvarez-Mon, Miguel A Delforge, Arnaud Sáez, Miguel A Coca, Santiago Sainz, Felipe Mon, Melchor Álvarez- Buján, Julia García-Honduvilla, Natalio |
author_facet | Ortega, Miguel A Asúnsolo, Ángel Pekarek, Leonel Alvarez-Mon, Miguel A Delforge, Arnaud Sáez, Miguel A Coca, Santiago Sainz, Felipe Mon, Melchor Álvarez- Buján, Julia García-Honduvilla, Natalio |
author_sort | Ortega, Miguel A |
collection | PubMed |
description | Chronic venous insufficiency (CVI) is one of the most common vascular pathologies worldwide. One of the risk factors for the development of CVI is aging, which is why it is related to senile changes. The main trigger of the changes that occur in the venous walls in CVI is blood flow reflux, which produces increased hydrostatic pressure, leading to valve incompetence. The cellular response is one of the fundamental processes in vascular diseases, causing the activation of cell signalling pathways such as c-Jun N-terminal kinase (JNK). Metabolic changes and calcifications occur in vascular pathology as a result of pathophysiological processes. The aim of this study was to determine the expression of JNK in venous disease and its relationship with the role played by the molecules involved in the osteogenic processes in venous tissue calcification. This was a cross-sectional study that analyzed the greater saphenous vein wall in 110 patients with (R) and without venous reflux (NR), classified according to age. Histopathological techniques were used and protein expression was analysed using immunohistochemistry techniques for JNK and markers of osteogenesis (RUNX2, osteocalcin (OCN), osteopontin (OPN)). Significantly increased JNK, RUNX2, OCN, OPN and pigment epithelium-derived factor (PEDF) protein expression and the presence of osseous metaplasia and amorphous calcification were observed in younger patients (<50 years) with venous reflux. This study shows for the first time the existence of an osteogenesis process related to the expression of JNK in the venous wall. |
format | Online Article Text |
id | pubmed-8040408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-80404082021-04-12 Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process Ortega, Miguel A Asúnsolo, Ángel Pekarek, Leonel Alvarez-Mon, Miguel A Delforge, Arnaud Sáez, Miguel A Coca, Santiago Sainz, Felipe Mon, Melchor Álvarez- Buján, Julia García-Honduvilla, Natalio Int J Med Sci Research Paper Chronic venous insufficiency (CVI) is one of the most common vascular pathologies worldwide. One of the risk factors for the development of CVI is aging, which is why it is related to senile changes. The main trigger of the changes that occur in the venous walls in CVI is blood flow reflux, which produces increased hydrostatic pressure, leading to valve incompetence. The cellular response is one of the fundamental processes in vascular diseases, causing the activation of cell signalling pathways such as c-Jun N-terminal kinase (JNK). Metabolic changes and calcifications occur in vascular pathology as a result of pathophysiological processes. The aim of this study was to determine the expression of JNK in venous disease and its relationship with the role played by the molecules involved in the osteogenic processes in venous tissue calcification. This was a cross-sectional study that analyzed the greater saphenous vein wall in 110 patients with (R) and without venous reflux (NR), classified according to age. Histopathological techniques were used and protein expression was analysed using immunohistochemistry techniques for JNK and markers of osteogenesis (RUNX2, osteocalcin (OCN), osteopontin (OPN)). Significantly increased JNK, RUNX2, OCN, OPN and pigment epithelium-derived factor (PEDF) protein expression and the presence of osseous metaplasia and amorphous calcification were observed in younger patients (<50 years) with venous reflux. This study shows for the first time the existence of an osteogenesis process related to the expression of JNK in the venous wall. Ivyspring International Publisher 2021-03-03 /pmc/articles/PMC8040408/ /pubmed/33850461 http://dx.doi.org/10.7150/ijms.54052 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Ortega, Miguel A Asúnsolo, Ángel Pekarek, Leonel Alvarez-Mon, Miguel A Delforge, Arnaud Sáez, Miguel A Coca, Santiago Sainz, Felipe Mon, Melchor Álvarez- Buján, Julia García-Honduvilla, Natalio Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process |
title | Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process |
title_full | Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process |
title_fullStr | Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process |
title_full_unstemmed | Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process |
title_short | Histopathological study of JNK in venous wall of patients with chronic venous insufficiency related to osteogenesis process |
title_sort | histopathological study of jnk in venous wall of patients with chronic venous insufficiency related to osteogenesis process |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040408/ https://www.ncbi.nlm.nih.gov/pubmed/33850461 http://dx.doi.org/10.7150/ijms.54052 |
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