Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis

The anti-cancer effects of Alisma canaliculatum extracts (ACE) were identified in AGS gastric cancer cells. Our results showed that ACE inhibited the growth of AGS cells, increased the proportion of sub-G1 phase cells, and depolarized the membrane potential of mitochondria. ACE-induced gastric cance...

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Detalles Bibliográficos
Autores principales: Kwon, Min Ji, Kim, Jeong Nam, Park, Joon, Kim, Yun Tai, Lee, Min Jae, Kim, Byung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040414/
https://www.ncbi.nlm.nih.gov/pubmed/33859522
http://dx.doi.org/10.7150/ijms.55212
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author Kwon, Min Ji
Kim, Jeong Nam
Park, Joon
Kim, Yun Tai
Lee, Min Jae
Kim, Byung Joo
author_facet Kwon, Min Ji
Kim, Jeong Nam
Park, Joon
Kim, Yun Tai
Lee, Min Jae
Kim, Byung Joo
author_sort Kwon, Min Ji
collection PubMed
description The anti-cancer effects of Alisma canaliculatum extracts (ACE) were identified in AGS gastric cancer cells. Our results showed that ACE inhibited the growth of AGS cells, increased the proportion of sub-G1 phase cells, and depolarized the membrane potential of mitochondria. ACE-induced gastric cancer cell death was associated with Bcl-2, survivin and Bax level changes, and it activated caspase-3 and -9. In addition, it was involved in the activation of MAPKs and increased the reactive oxygen species (ROS). These results suggest that ACE induces apoptosis in AGS gastric cancer cells, and therefore, ACE may have the potential to treat gastric cancer.
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spelling pubmed-80404142021-04-14 Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis Kwon, Min Ji Kim, Jeong Nam Park, Joon Kim, Yun Tai Lee, Min Jae Kim, Byung Joo Int J Med Sci Research Paper The anti-cancer effects of Alisma canaliculatum extracts (ACE) were identified in AGS gastric cancer cells. Our results showed that ACE inhibited the growth of AGS cells, increased the proportion of sub-G1 phase cells, and depolarized the membrane potential of mitochondria. ACE-induced gastric cancer cell death was associated with Bcl-2, survivin and Bax level changes, and it activated caspase-3 and -9. In addition, it was involved in the activation of MAPKs and increased the reactive oxygen species (ROS). These results suggest that ACE induces apoptosis in AGS gastric cancer cells, and therefore, ACE may have the potential to treat gastric cancer. Ivyspring International Publisher 2021-03-19 /pmc/articles/PMC8040414/ /pubmed/33859522 http://dx.doi.org/10.7150/ijms.55212 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Kwon, Min Ji
Kim, Jeong Nam
Park, Joon
Kim, Yun Tai
Lee, Min Jae
Kim, Byung Joo
Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis
title Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis
title_full Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis
title_fullStr Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis
title_full_unstemmed Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis
title_short Alisma canaliculatum Extract Affects AGS Gastric Cancer Cells by Inducing Apoptosis
title_sort alisma canaliculatum extract affects ags gastric cancer cells by inducing apoptosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040414/
https://www.ncbi.nlm.nih.gov/pubmed/33859522
http://dx.doi.org/10.7150/ijms.55212
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