Macrophage Activation in COVID-19 Patients in Intensive Care Unit

We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountere...

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Detalles Bibliográficos
Autores principales: Labro, Guylaine, Jandeaux, Louise Marie, Rusu, Andreea, Virot, Edouard, Pointurier, Valentin, Pinto, Luis, Mathien, Cyrille, Debliquis, Agathe, Harzallah, Ines, Mootien, Joy, Drenou, Bernard, Kuteifan, Khaldoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040439/
https://www.ncbi.nlm.nih.gov/pubmed/33984075
http://dx.doi.org/10.14740/jmc3520
Descripción
Sumario:We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH).

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