Macrophage Activation in COVID-19 Patients in Intensive Care Unit

We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountere...

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Autores principales: Labro, Guylaine, Jandeaux, Louise Marie, Rusu, Andreea, Virot, Edouard, Pointurier, Valentin, Pinto, Luis, Mathien, Cyrille, Debliquis, Agathe, Harzallah, Ines, Mootien, Joy, Drenou, Bernard, Kuteifan, Khaldoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040439/
https://www.ncbi.nlm.nih.gov/pubmed/33984075
http://dx.doi.org/10.14740/jmc3520
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author Labro, Guylaine
Jandeaux, Louise Marie
Rusu, Andreea
Virot, Edouard
Pointurier, Valentin
Pinto, Luis
Mathien, Cyrille
Debliquis, Agathe
Harzallah, Ines
Mootien, Joy
Drenou, Bernard
Kuteifan, Khaldoun
author_facet Labro, Guylaine
Jandeaux, Louise Marie
Rusu, Andreea
Virot, Edouard
Pointurier, Valentin
Pinto, Luis
Mathien, Cyrille
Debliquis, Agathe
Harzallah, Ines
Mootien, Joy
Drenou, Bernard
Kuteifan, Khaldoun
author_sort Labro, Guylaine
collection PubMed
description We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH).
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spelling pubmed-80404392021-04-26 Macrophage Activation in COVID-19 Patients in Intensive Care Unit Labro, Guylaine Jandeaux, Louise Marie Rusu, Andreea Virot, Edouard Pointurier, Valentin Pinto, Luis Mathien, Cyrille Debliquis, Agathe Harzallah, Ines Mootien, Joy Drenou, Bernard Kuteifan, Khaldoun J Med Cases Case Report We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH). Elmer Press 2020-07 2020-06-29 /pmc/articles/PMC8040439/ /pubmed/33984075 http://dx.doi.org/10.14740/jmc3520 Text en Copyright 2020, Labro et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Labro, Guylaine
Jandeaux, Louise Marie
Rusu, Andreea
Virot, Edouard
Pointurier, Valentin
Pinto, Luis
Mathien, Cyrille
Debliquis, Agathe
Harzallah, Ines
Mootien, Joy
Drenou, Bernard
Kuteifan, Khaldoun
Macrophage Activation in COVID-19 Patients in Intensive Care Unit
title Macrophage Activation in COVID-19 Patients in Intensive Care Unit
title_full Macrophage Activation in COVID-19 Patients in Intensive Care Unit
title_fullStr Macrophage Activation in COVID-19 Patients in Intensive Care Unit
title_full_unstemmed Macrophage Activation in COVID-19 Patients in Intensive Care Unit
title_short Macrophage Activation in COVID-19 Patients in Intensive Care Unit
title_sort macrophage activation in covid-19 patients in intensive care unit
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040439/
https://www.ncbi.nlm.nih.gov/pubmed/33984075
http://dx.doi.org/10.14740/jmc3520
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