A Case of COVID-19 Failed in Viral Identification but Showed Consistent Host Responses to Severe Acute Respiratory Syndrome Coronavirus 2

In a 75-year-old hemodialysis patient, pneumonia manifested with computed tomography (CT) images suggestive of coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) was not detected with repeated polymerase chain reaction (PCR) tests...

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Autores principales: Maeda, Yoshitaka, Miyo, Hiroyuki, Ohashi, Atsuki, Yamamoto, Takanobu, Ogata, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040448/
https://www.ncbi.nlm.nih.gov/pubmed/33984084
http://dx.doi.org/10.14740/jmc3566
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author Maeda, Yoshitaka
Miyo, Hiroyuki
Ohashi, Atsuki
Yamamoto, Takanobu
Ogata, Tomoyuki
author_facet Maeda, Yoshitaka
Miyo, Hiroyuki
Ohashi, Atsuki
Yamamoto, Takanobu
Ogata, Tomoyuki
author_sort Maeda, Yoshitaka
collection PubMed
description In a 75-year-old hemodialysis patient, pneumonia manifested with computed tomography (CT) images suggestive of coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) was not detected with repeated polymerase chain reaction (PCR) tests, but serum immunoglobulin G (IgG) and IgM antibodies against SARS-CoV-2 turned positive with two different assay kits. The patient was thus treated as a probable COVID-19 case, and then recovered through the intensive care including ciclesonide, favipiravir, and methyl prednisolone. In PCR-negative cases, the diagnosis of COVID-19 cannot be established at present, but such COVID-19 cases certainly exist. To avoid a delay in treatment of COVID-19, available diagnostic tools should be utilized with careful attention for their limitations.
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spelling pubmed-80404482021-04-26 A Case of COVID-19 Failed in Viral Identification but Showed Consistent Host Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Maeda, Yoshitaka Miyo, Hiroyuki Ohashi, Atsuki Yamamoto, Takanobu Ogata, Tomoyuki J Med Cases Case Report In a 75-year-old hemodialysis patient, pneumonia manifested with computed tomography (CT) images suggestive of coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) was not detected with repeated polymerase chain reaction (PCR) tests, but serum immunoglobulin G (IgG) and IgM antibodies against SARS-CoV-2 turned positive with two different assay kits. The patient was thus treated as a probable COVID-19 case, and then recovered through the intensive care including ciclesonide, favipiravir, and methyl prednisolone. In PCR-negative cases, the diagnosis of COVID-19 cannot be established at present, but such COVID-19 cases certainly exist. To avoid a delay in treatment of COVID-19, available diagnostic tools should be utilized with careful attention for their limitations. Elmer Press 2020-10 2020-08-28 /pmc/articles/PMC8040448/ /pubmed/33984084 http://dx.doi.org/10.14740/jmc3566 Text en Copyright 2020, Maeda et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Maeda, Yoshitaka
Miyo, Hiroyuki
Ohashi, Atsuki
Yamamoto, Takanobu
Ogata, Tomoyuki
A Case of COVID-19 Failed in Viral Identification but Showed Consistent Host Responses to Severe Acute Respiratory Syndrome Coronavirus 2
title A Case of COVID-19 Failed in Viral Identification but Showed Consistent Host Responses to Severe Acute Respiratory Syndrome Coronavirus 2
title_full A Case of COVID-19 Failed in Viral Identification but Showed Consistent Host Responses to Severe Acute Respiratory Syndrome Coronavirus 2
title_fullStr A Case of COVID-19 Failed in Viral Identification but Showed Consistent Host Responses to Severe Acute Respiratory Syndrome Coronavirus 2
title_full_unstemmed A Case of COVID-19 Failed in Viral Identification but Showed Consistent Host Responses to Severe Acute Respiratory Syndrome Coronavirus 2
title_short A Case of COVID-19 Failed in Viral Identification but Showed Consistent Host Responses to Severe Acute Respiratory Syndrome Coronavirus 2
title_sort case of covid-19 failed in viral identification but showed consistent host responses to severe acute respiratory syndrome coronavirus 2
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040448/
https://www.ncbi.nlm.nih.gov/pubmed/33984084
http://dx.doi.org/10.14740/jmc3566
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