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Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling

Implant-derived wear particles can be phagocytosed by local macrophages, triggering an inflammatory cascade that can drive the activation and recruitment of osteoclasts, thereby inducing peri-prosthetic osteolysis. Efforts to suppress pro-inflammatory cytokine release and osteoclastsogenesis thus re...

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Detalles Bibliográficos
Autores principales:	Li, Ning, Li, Xiaoping, Zheng, Kai, Bai, Jiaxiang, Zhang, Weicheng, Sun, Houyi, Ge, Gaoran, Wang, Wei, Wang, Zhen, Gu, Ye, Xue, Yi, Xu, Yaozeng, Geng, Dechun, Zhou, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040473/ https://www.ncbi.nlm.nih.gov/pubmed/33867853 http://dx.doi.org/10.7150/ijbs.53992

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