Long-term survival of an ovarian cancer patient harboring a RAD51C missense mutation

Mutations in homologous recombination (HR) genes predispose to cancer but also sensitize to chemotherapeutics. Although therapy can initially be effective, cancers frequently cease responding, leading to recurrence and poor prognosis. Here we identify a germline mutation in RAD51C, a critical HR fac...

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Detalles Bibliográficos
Autores principales: Sullivan, Meghan R., Prakash, Rohit, Rawal, Yashpal, Wang, Weibin, Sung, Patrick, Radke, Marc R., Kaufmann, Scott H., Swisher, Elizabeth M., Bernstein, Kara A., Jasin, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040731/
https://www.ncbi.nlm.nih.gov/pubmed/33832919
http://dx.doi.org/10.1101/mcs.a006083

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