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Assessing acquired resistance to IDH1 inhibitor therapy by full-exon IDH1 sequencing and structural modeling

Somatic mutations in hotspot regions of the cytosolic or mitochondrial isoforms of the isocitrate dehydrogenase gene (IDH1 and IDH2, respectively) contribute to the pathogenesis of acute myeloid leukemia (AML) by producing the oncometabolite 2-hydroxyglutarate (2-HG). The allosteric IDH1 inhibitor,...

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Detalles Bibliográficos
Autores principales:	Oltvai, Zoltán N., Harley, Susan E., Koes, David, Michel, Stephen, Warlick, Erica D., Nelson, Andrew C., Yohe, Sophia, Mroz, Pawel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040736/ https://www.ncbi.nlm.nih.gov/pubmed/33832922 http://dx.doi.org/10.1101/mcs.a006007

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