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Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study

BACKGROUND: Timely detection of the progression of the highly contagious coronavirus disease (COVID-19) is of utmost importance for management and intervention for patients in intensive care (ICU). AIM: This study aims to better understand this new infection and report the changes in the various lab...

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Autores principales: Ghaith, Mazen M., Albanghali, Mohammad A., Aldairi, Abdullah F., Iqbal, Mohammad S., Almaimani, Riyad A., AlQuthami, Khalid, Alqasmi, Mansour H., Almaimani, Wail, El-Readi, Mahmoud Zaki, Alghamdi, Ahmad, Almasmoum, Hussain A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040927/
https://www.ncbi.nlm.nih.gov/pubmed/33884042
http://dx.doi.org/10.1155/2021/6656092
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author Ghaith, Mazen M.
Albanghali, Mohammad A.
Aldairi, Abdullah F.
Iqbal, Mohammad S.
Almaimani, Riyad A.
AlQuthami, Khalid
Alqasmi, Mansour H.
Almaimani, Wail
El-Readi, Mahmoud Zaki
Alghamdi, Ahmad
Almasmoum, Hussain A
author_facet Ghaith, Mazen M.
Albanghali, Mohammad A.
Aldairi, Abdullah F.
Iqbal, Mohammad S.
Almaimani, Riyad A.
AlQuthami, Khalid
Alqasmi, Mansour H.
Almaimani, Wail
El-Readi, Mahmoud Zaki
Alghamdi, Ahmad
Almasmoum, Hussain A
author_sort Ghaith, Mazen M.
collection PubMed
description BACKGROUND: Timely detection of the progression of the highly contagious coronavirus disease (COVID-19) is of utmost importance for management and intervention for patients in intensive care (ICU). AIM: This study aims to better understand this new infection and report the changes in the various laboratory tests identified in critically ill patients and associated with poor prognosis among COVID-19 patients admitted to the ICU. METHODS: This was a retrospective study that included 160 confirmed SARS-CoV-2-positive patients. RESULTS: Elevated serum ferritin, D-dimer, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and nonconjugated bilirubin levels were present in 139 (96%), 131 (96%), 107 (68%), 52 (34%), and 89 (70%) patients, respectively. Renal parameters were abnormal in a significant number of cases with elevated creatinine and blood urea nitrogen in 93 (62%) and 102 (68%) cases, respectively. Hematological profiles revealed lower red blood cell count, hemoglobin, eosinophils, basophils, monocytes, and lymphocytes in 90 (57%), 103 (65%), 89 (62%), 105 (73%), 35 (24%), and 119 (83%) cases, respectively. The neutrophil count was found to increase in 71.3% of the cases. There was significantly higher mortality (83%) among patients older than 60 years (p=0.001) and in female patients (75%) (p=0.012). Patients with lung diseases had a poor outcome compared to patients with other comorbidities (p=0.002). There was a significant association between elevated D-dimer levels and increased mortality (p=0.003). Elevated levels of AST, creatinine, blood urea nitrogen, and bilirubin were significantly associated with unfavorable outcomes. CONCLUSION: Different parameters can be used to predict disease prognosis, especially the risk of poor prognosis. Accurate diagnosis and monitoring of disease progression from the early stages will help in reducing mortality and unfavorable outcomes.
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spelling pubmed-80409272021-04-20 Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study Ghaith, Mazen M. Albanghali, Mohammad A. Aldairi, Abdullah F. Iqbal, Mohammad S. Almaimani, Riyad A. AlQuthami, Khalid Alqasmi, Mansour H. Almaimani, Wail El-Readi, Mahmoud Zaki Alghamdi, Ahmad Almasmoum, Hussain A Can J Infect Dis Med Microbiol Research Article BACKGROUND: Timely detection of the progression of the highly contagious coronavirus disease (COVID-19) is of utmost importance for management and intervention for patients in intensive care (ICU). AIM: This study aims to better understand this new infection and report the changes in the various laboratory tests identified in critically ill patients and associated with poor prognosis among COVID-19 patients admitted to the ICU. METHODS: This was a retrospective study that included 160 confirmed SARS-CoV-2-positive patients. RESULTS: Elevated serum ferritin, D-dimer, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and nonconjugated bilirubin levels were present in 139 (96%), 131 (96%), 107 (68%), 52 (34%), and 89 (70%) patients, respectively. Renal parameters were abnormal in a significant number of cases with elevated creatinine and blood urea nitrogen in 93 (62%) and 102 (68%) cases, respectively. Hematological profiles revealed lower red blood cell count, hemoglobin, eosinophils, basophils, monocytes, and lymphocytes in 90 (57%), 103 (65%), 89 (62%), 105 (73%), 35 (24%), and 119 (83%) cases, respectively. The neutrophil count was found to increase in 71.3% of the cases. There was significantly higher mortality (83%) among patients older than 60 years (p=0.001) and in female patients (75%) (p=0.012). Patients with lung diseases had a poor outcome compared to patients with other comorbidities (p=0.002). There was a significant association between elevated D-dimer levels and increased mortality (p=0.003). Elevated levels of AST, creatinine, blood urea nitrogen, and bilirubin were significantly associated with unfavorable outcomes. CONCLUSION: Different parameters can be used to predict disease prognosis, especially the risk of poor prognosis. Accurate diagnosis and monitoring of disease progression from the early stages will help in reducing mortality and unfavorable outcomes. Hindawi 2021-04-12 /pmc/articles/PMC8040927/ /pubmed/33884042 http://dx.doi.org/10.1155/2021/6656092 Text en Copyright © 2021 Mazen M. Ghaith et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ghaith, Mazen M.
Albanghali, Mohammad A.
Aldairi, Abdullah F.
Iqbal, Mohammad S.
Almaimani, Riyad A.
AlQuthami, Khalid
Alqasmi, Mansour H.
Almaimani, Wail
El-Readi, Mahmoud Zaki
Alghamdi, Ahmad
Almasmoum, Hussain A
Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study
title Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study
title_full Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study
title_fullStr Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study
title_full_unstemmed Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study
title_short Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study
title_sort potential predictors of poor prognosis among severe covid-19 patients: a single-center study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040927/
https://www.ncbi.nlm.nih.gov/pubmed/33884042
http://dx.doi.org/10.1155/2021/6656092
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