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Hysteroscopy Findings after Two Previous Failed In vitro Fertilisation Cycles: A Case for Routine Hysteroscopy before In vitro Fertilisation?
BACKGROUND: The success rates of in vitro fertilisation (IVF) cycles have remained low. The condition of the uterus plays a significant role in the IVF treatment outcome. Unfortunately, some uterine pathologies are missed on routine ultrasound scans performed before IVF. OBJECTIVE: To document the h...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040942/ https://www.ncbi.nlm.nih.gov/pubmed/33888927 http://dx.doi.org/10.4103/nmj.NMJ_112_20 |
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author | Okohue, Jude Ehiabhi Onuh, Sunday Omale Okohue, Joy Ose |
author_facet | Okohue, Jude Ehiabhi Onuh, Sunday Omale Okohue, Joy Ose |
author_sort | Okohue, Jude Ehiabhi |
collection | PubMed |
description | BACKGROUND: The success rates of in vitro fertilisation (IVF) cycles have remained low. The condition of the uterus plays a significant role in the IVF treatment outcome. Unfortunately, some uterine pathologies are missed on routine ultrasound scans performed before IVF. OBJECTIVE: To document the hysteroscopy findings following normal ultrasound scan endometrial assessments in women with two previous failed IVF cycles, seen at a private fertility unit. MATERIALS AND METHODS: This is a retrospective descriptive study. The electronic medical records were retrieved for patients who underwent hysteroscopy after two consecutive failed IVF cycles despite normal ultrasound scan findings between April 1, 2010, and March 31, 2017. Data, including age, findings at hysteroscopy, and IVF/intracytoplasmic sperm injection treatment outcomes following hysteroscopy, were documented. The results are presented as frequency distribution tables. RESULTS: A total of 77 patients had normal ultrasound scan findings after two previous failed IVF cycles, requiring a hysteroscopy during the study period. This represented 7.7% of the 1,002 hysteroscopies performed during the same period. The age range was 25–54 years, with a mean age of 37 ± 4.3 years. A majority of the women (59, 76.6%) had no pathology on hysteroscopy, while 14 (18.2%) had intrauterine adhesions. Three patients (3.9%) had endometrial polyps, and one patient (1.3%) had a subseptate uterus. Following hysteroscopy, 24 patients (31.2%) became pregnant, 29 patients (37.6%) had failed IVF cycles, while the remaining 24 patients (31.2%) were lost to follow up. CONCLUSION: This study has added to the body of evidence that suggests that routine hysteroscopy before IVF is capable of picking up missed pathologies that might otherwise negatively impart IVF success rates. More RCT are, however, needed to determine the effect of routine hysteroscopy on IVF treatment outcomes. |
format | Online Article Text |
id | pubmed-8040942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-80409422021-04-21 Hysteroscopy Findings after Two Previous Failed In vitro Fertilisation Cycles: A Case for Routine Hysteroscopy before In vitro Fertilisation? Okohue, Jude Ehiabhi Onuh, Sunday Omale Okohue, Joy Ose Niger Med J Original Article BACKGROUND: The success rates of in vitro fertilisation (IVF) cycles have remained low. The condition of the uterus plays a significant role in the IVF treatment outcome. Unfortunately, some uterine pathologies are missed on routine ultrasound scans performed before IVF. OBJECTIVE: To document the hysteroscopy findings following normal ultrasound scan endometrial assessments in women with two previous failed IVF cycles, seen at a private fertility unit. MATERIALS AND METHODS: This is a retrospective descriptive study. The electronic medical records were retrieved for patients who underwent hysteroscopy after two consecutive failed IVF cycles despite normal ultrasound scan findings between April 1, 2010, and March 31, 2017. Data, including age, findings at hysteroscopy, and IVF/intracytoplasmic sperm injection treatment outcomes following hysteroscopy, were documented. The results are presented as frequency distribution tables. RESULTS: A total of 77 patients had normal ultrasound scan findings after two previous failed IVF cycles, requiring a hysteroscopy during the study period. This represented 7.7% of the 1,002 hysteroscopies performed during the same period. The age range was 25–54 years, with a mean age of 37 ± 4.3 years. A majority of the women (59, 76.6%) had no pathology on hysteroscopy, while 14 (18.2%) had intrauterine adhesions. Three patients (3.9%) had endometrial polyps, and one patient (1.3%) had a subseptate uterus. Following hysteroscopy, 24 patients (31.2%) became pregnant, 29 patients (37.6%) had failed IVF cycles, while the remaining 24 patients (31.2%) were lost to follow up. CONCLUSION: This study has added to the body of evidence that suggests that routine hysteroscopy before IVF is capable of picking up missed pathologies that might otherwise negatively impart IVF success rates. More RCT are, however, needed to determine the effect of routine hysteroscopy on IVF treatment outcomes. Wolters Kluwer - Medknow 2020 2020-12-19 /pmc/articles/PMC8040942/ /pubmed/33888927 http://dx.doi.org/10.4103/nmj.NMJ_112_20 Text en Copyright: © 2020 Nigerian Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Okohue, Jude Ehiabhi Onuh, Sunday Omale Okohue, Joy Ose Hysteroscopy Findings after Two Previous Failed In vitro Fertilisation Cycles: A Case for Routine Hysteroscopy before In vitro Fertilisation? |
title | Hysteroscopy Findings after Two Previous Failed In vitro Fertilisation Cycles: A Case for Routine Hysteroscopy before In vitro Fertilisation? |
title_full | Hysteroscopy Findings after Two Previous Failed In vitro Fertilisation Cycles: A Case for Routine Hysteroscopy before In vitro Fertilisation? |
title_fullStr | Hysteroscopy Findings after Two Previous Failed In vitro Fertilisation Cycles: A Case for Routine Hysteroscopy before In vitro Fertilisation? |
title_full_unstemmed | Hysteroscopy Findings after Two Previous Failed In vitro Fertilisation Cycles: A Case for Routine Hysteroscopy before In vitro Fertilisation? |
title_short | Hysteroscopy Findings after Two Previous Failed In vitro Fertilisation Cycles: A Case for Routine Hysteroscopy before In vitro Fertilisation? |
title_sort | hysteroscopy findings after two previous failed in vitro fertilisation cycles: a case for routine hysteroscopy before in vitro fertilisation? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040942/ https://www.ncbi.nlm.nih.gov/pubmed/33888927 http://dx.doi.org/10.4103/nmj.NMJ_112_20 |
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