Severe oligomeric tau toxicity can be reversed without long-term sequelae

Tau is a microtubule stabilizing protein that forms abnormal aggregates in many neurodegenerative disorders, including Alzheimer’s disease. We have previously shown that co-expression of fragmented and full-length tau in P301SxTAU62(on) tau transgenic mice results in the formation of oligomeric tau...

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Detalles Bibliográficos
Autores principales: Martinisi, Alfonso, Flach, Martin, Sprenger, Frederik, Frank, Stephan, Tolnay, Markus, Winkler, David T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041046/
https://www.ncbi.nlm.nih.gov/pubmed/33484116
http://dx.doi.org/10.1093/brain/awaa445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041046/
https://www.ncbi.nlm.nih.gov/pubmed/33484116
http://dx.doi.org/10.1093/brain/awaa445

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