COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin

There have been limited cases linking SARS-CoV-2 infection with the development of reversible cerebral vasoconstriction syndrome (RCVS). We hereby report a rare case of RCVS in the setting of mild SARS-CoV-2 respiratory infection successfully treated with nimodipine and aspirin. SARS-CoV-2 attacks t...

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Autores principales: Mansoor, Tarab, Alsarah, Ali A., Mousavi, Hossein, Khader Eliyas, Javed, Girotra, Tarun, Hussein, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041144/
https://www.ncbi.nlm.nih.gov/pubmed/33895426
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105822
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author Mansoor, Tarab
Alsarah, Ali A.
Mousavi, Hossein
Khader Eliyas, Javed
Girotra, Tarun
Hussein, Omar
author_facet Mansoor, Tarab
Alsarah, Ali A.
Mousavi, Hossein
Khader Eliyas, Javed
Girotra, Tarun
Hussein, Omar
author_sort Mansoor, Tarab
collection PubMed
description There have been limited cases linking SARS-CoV-2 infection with the development of reversible cerebral vasoconstriction syndrome (RCVS). We hereby report a rare case of RCVS in the setting of mild SARS-CoV-2 respiratory infection successfully treated with nimodipine and aspirin. SARS-CoV-2 attacks the ACE2-receptors, which are expressed in various body organs including the lungs, kidneys, and blood vessels. Vasoconstriction can result from down-regulation of the ACE2-receptors that can lead to sympathetic hypertonia of the cerebral blood vessel walls and/or over-activation of the renin-angiotensin axis.
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spelling pubmed-80411442021-04-13 COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin Mansoor, Tarab Alsarah, Ali A. Mousavi, Hossein Khader Eliyas, Javed Girotra, Tarun Hussein, Omar J Stroke Cerebrovasc Dis Case Report There have been limited cases linking SARS-CoV-2 infection with the development of reversible cerebral vasoconstriction syndrome (RCVS). We hereby report a rare case of RCVS in the setting of mild SARS-CoV-2 respiratory infection successfully treated with nimodipine and aspirin. SARS-CoV-2 attacks the ACE2-receptors, which are expressed in various body organs including the lungs, kidneys, and blood vessels. Vasoconstriction can result from down-regulation of the ACE2-receptors that can lead to sympathetic hypertonia of the cerebral blood vessel walls and/or over-activation of the renin-angiotensin axis. Elsevier Inc. 2021-07 2021-04-12 /pmc/articles/PMC8041144/ /pubmed/33895426 http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105822 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Mansoor, Tarab
Alsarah, Ali A.
Mousavi, Hossein
Khader Eliyas, Javed
Girotra, Tarun
Hussein, Omar
COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
title COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
title_full COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
title_fullStr COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
title_full_unstemmed COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
title_short COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
title_sort covid-19 associated reversible cerebral vasoconstriction syndrome successfully treated with nimodipine and aspirin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041144/
https://www.ncbi.nlm.nih.gov/pubmed/33895426
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105822
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