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TcpC inhibits toll-like receptor signaling pathway by serving as an E3 ubiquitin ligase that promotes degradation of myeloid differentiation factor 88

TcpC is a virulence factor of uropathogenic E. coli (UPEC). It was found that TIR domain of TcpC impedes TLR signaling by direct association with MyD88. It has been a long-standing question whether bacterial pathogens have evolved a mechanism to manipulate MyD88 degradation by ubiquitin-proteasome p...

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Detalles Bibliográficos
Autores principales:	Fang, Jia-qi, Ou, Qian, Pan, Jun, Fang, Jie, Zhang, Da-yong, Qiu, Miao-qi, Li, Yue-qi, Wang, Xiao-Hui, Yang, Xue-yu, Chi, Zhe, Gao, Wei, Guo, Jun-ping, Miethke, Thomas, Pan, Jian-ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041205/ https://www.ncbi.nlm.nih.gov/pubmed/33788895 http://dx.doi.org/10.1371/journal.ppat.1009481

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