2-Phenyl-1H-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT(6) Receptor Inverse Agonists with Cognition-Enhancing Activity

[Image: see text] Serotonin type 6 receptor (5-HT(6)R) has gained particular interest as a promising target for treating cognitive deficits, given the positive effects of its antagonists in a wide range of memory impairment paradigms. Herein, we report on degradation of the 1H-pyrrolo[3,2-c]quinolin...

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Detalles Bibliográficos
Autores principales: Drop, Marcin, Canale, Vittorio, Chaumont-Dubel, Séverine, Kurczab, Rafał, Satała, Grzegorz, Bantreil, Xavier, Walczak, Maria, Koczurkiewicz-Adamczyk, Paulina, Latacz, Gniewomir, Gwizdak, Anna, Krawczyk, Martyna, Gołębiowska, Joanna, Grychowska, Katarzyna, Bojarski, Andrzej J., Nikiforuk, Agnieszka, Subra, Gilles, Martinez, Jean, Pawłowski, Maciej, Popik, Piotr, Marin, Philippe, Lamaty, Frédéric, Zajdel, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041276/
https://www.ncbi.nlm.nih.gov/pubmed/33705101
http://dx.doi.org/10.1021/acschemneuro.1c00061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041276/
https://www.ncbi.nlm.nih.gov/pubmed/33705101
http://dx.doi.org/10.1021/acschemneuro.1c00061

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