Structure–Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity

[Image: see text] Neuropeptide S modulates important neurobiological functions including locomotion, anxiety, and drug abuse through interaction with its G protein-coupled receptor known as neuropeptide S receptor (NPSR). NPSR antagonists are potentially useful for the treatment of substance abuse d...

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Detalles Bibliográficos
Autores principales: Albanese, Valentina, Ruzza, Chiara, Marzola, Erika, Bernardi, Tatiana, Fabbri, Martina, Fantinati, Anna, Trapella, Claudio, Reinscheid, Rainer K., Ferrari, Federica, Sturaro, Chiara, Calò, Girolamo, Amendola, Giorgio, Cosconati, Sandro, Pacifico, Salvatore, Guerrini, Remo, Preti, Delia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041306/
https://www.ncbi.nlm.nih.gov/pubmed/33733768
http://dx.doi.org/10.1021/acs.jmedchem.0c02223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041306/
https://www.ncbi.nlm.nih.gov/pubmed/33733768
http://dx.doi.org/10.1021/acs.jmedchem.0c02223

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