A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles

[Image: see text] 3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing them to be chemoselectively derivatized with high...

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Autores principales: García-Vázquez, Víctor, Hoteite, Larry, Lakeland, Christopher P., Watson, David W., Harrity, Joseph P. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041373/
https://www.ncbi.nlm.nih.gov/pubmed/33759534
http://dx.doi.org/10.1021/acs.orglett.1c00752
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author García-Vázquez, Víctor
Hoteite, Larry
Lakeland, Christopher P.
Watson, David W.
Harrity, Joseph P. A.
author_facet García-Vázquez, Víctor
Hoteite, Larry
Lakeland, Christopher P.
Watson, David W.
Harrity, Joseph P. A.
author_sort García-Vázquez, Víctor
collection PubMed
description [Image: see text] 3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing them to be chemoselectively derivatized with high diastereocontrol.
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spelling pubmed-80413732021-04-13 A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles García-Vázquez, Víctor Hoteite, Larry Lakeland, Christopher P. Watson, David W. Harrity, Joseph P. A. Org Lett [Image: see text] 3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing them to be chemoselectively derivatized with high diastereocontrol. American Chemical Society 2021-03-24 2021-04-02 /pmc/articles/PMC8041373/ /pubmed/33759534 http://dx.doi.org/10.1021/acs.orglett.1c00752 Text en © 2021 American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle García-Vázquez, Víctor
Hoteite, Larry
Lakeland, Christopher P.
Watson, David W.
Harrity, Joseph P. A.
A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles
title A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles
title_full A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles
title_fullStr A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles
title_full_unstemmed A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles
title_short A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles
title_sort pd-catalyzed [4 + 2] annulation approach to fluorinated n-heterocycles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041373/
https://www.ncbi.nlm.nih.gov/pubmed/33759534
http://dx.doi.org/10.1021/acs.orglett.1c00752
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