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Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

[Image: see text] Human liver microsomes (HLM) and human hepatocytes (HH) are important in vitro systems for studies of intrinsic drug clearance (CL(int)) in the liver. However, the CL(int) values are often in disagreement for these two systems. Here, we investigated these differences in a side-by-s...

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Detalles Bibliográficos
Autores principales:	Wegler, Christine, Matsson, Pär, Krogstad, Veronica, Urdzik, Jozef, Christensen, Hege, Andersson, Tommy B., Artursson, Per
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041379/ https://www.ncbi.nlm.nih.gov/pubmed/33739838 http://dx.doi.org/10.1021/acs.molpharmaceut.1c00053

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