Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt

Poor solubility of drug candidates mainly affects bioavailability, but poor solubility of drugs and metabolites can also lead to precipitation within tissues, particularly when high doses are tested. RO0728617 is an amphoteric compound bearing basic and acidic moieties that has previously demonstrat...

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Detalles Bibliográficos
Autores principales: Lenz, Barbara, Brink, Andreas, Mihatsch, Michael J, Altmann, Bernd, Niederhauser, Urs, Steinhuber, Bernd, Wyttenbach, Nicole, Fischer, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Regulatory Science, Risk Assessment, and Decision Making
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041455/
https://www.ncbi.nlm.nih.gov/pubmed/33454789
http://dx.doi.org/10.1093/toxsci/kfaa191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041455/
https://www.ncbi.nlm.nih.gov/pubmed/33454789
http://dx.doi.org/10.1093/toxsci/kfaa191

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