Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans

Omecamtiv mecarbil (OM) is a promising novel drug for improving cardiac contractility. We tested the therapeutic range of OM and identified previously unrecognized side effects. The Ca(2+) sensitivity of isometric force production (pCa(50)) and force at low Ca(2+) levels increased with OM concentrat...

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Detalles Bibliográficos
Autores principales: Fülöp, Gábor Á., Oláh, Attila, Csipo, Tamas, Kovács, Árpád, Pórszász, Róbert, Veress, Roland, Horváth, Balázs, Nagy, László, Bódi, Beáta, Fagyas, Miklós, Helgadottir, Solveig Lind, Bánhegyi, Viktor, Juhász, Béla, Bombicz, Mariann, Priksz, Daniel, Nanasi, Peter, Merkely, Béla, Édes, István, Csanádi, Zoltán, Papp, Zoltán, Radovits, Tamás, Tóth, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041714/
https://www.ncbi.nlm.nih.gov/pubmed/33844095
http://dx.doi.org/10.1007/s00395-021-00866-8

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