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Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava

Robustness, a naïve property of biological systems, enables organisms to maintain functions during perturbation and is crucial for improving the resilience of crops to prevailing stress conditions and diseases, guaranteeing food security. Most studies of robustness in crops have focused on genetic s...

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Autores principales: Jaemthaworn, Thanakorn, Kalapanulak, Saowalak, Saithong, Treenut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041763/
https://www.ncbi.nlm.nih.gov/pubmed/33846415
http://dx.doi.org/10.1038/s41598-021-86806-x
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author Jaemthaworn, Thanakorn
Kalapanulak, Saowalak
Saithong, Treenut
author_facet Jaemthaworn, Thanakorn
Kalapanulak, Saowalak
Saithong, Treenut
author_sort Jaemthaworn, Thanakorn
collection PubMed
description Robustness, a naïve property of biological systems, enables organisms to maintain functions during perturbation and is crucial for improving the resilience of crops to prevailing stress conditions and diseases, guaranteeing food security. Most studies of robustness in crops have focused on genetic superiority based upon individual genes, overlooking the collaborative actions of multiple responsive genes and the regulatory network topology. This research aims to uncover patterns of gene cooperation leading to organismal robustness by studying the topology of gene co-expression networks (GCNs) of both CBSV virus resistant and susceptible cassava cultivars. The resulting GCNs show higher topological clustering of cooperative genes in the resistant cultivar, suggesting that the network architecture is central to attaining robustness. Despite a reduction in the number of hub genes in the resistant cultivar following the perturbation, essential biological functions contained in the network were maintained through neighboring genes that withstood the shock. The susceptible cultivar seemingly coped by inducing more gene actions in the network but could not maintain the functions required for plant growth. These findings underscore the importance of regulatory network architecture in ensuring phenotypic robustness and deepen our understanding of transcriptional regulation.
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spelling pubmed-80417632021-04-13 Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava Jaemthaworn, Thanakorn Kalapanulak, Saowalak Saithong, Treenut Sci Rep Article Robustness, a naïve property of biological systems, enables organisms to maintain functions during perturbation and is crucial for improving the resilience of crops to prevailing stress conditions and diseases, guaranteeing food security. Most studies of robustness in crops have focused on genetic superiority based upon individual genes, overlooking the collaborative actions of multiple responsive genes and the regulatory network topology. This research aims to uncover patterns of gene cooperation leading to organismal robustness by studying the topology of gene co-expression networks (GCNs) of both CBSV virus resistant and susceptible cassava cultivars. The resulting GCNs show higher topological clustering of cooperative genes in the resistant cultivar, suggesting that the network architecture is central to attaining robustness. Despite a reduction in the number of hub genes in the resistant cultivar following the perturbation, essential biological functions contained in the network were maintained through neighboring genes that withstood the shock. The susceptible cultivar seemingly coped by inducing more gene actions in the network but could not maintain the functions required for plant growth. These findings underscore the importance of regulatory network architecture in ensuring phenotypic robustness and deepen our understanding of transcriptional regulation. Nature Publishing Group UK 2021-04-12 /pmc/articles/PMC8041763/ /pubmed/33846415 http://dx.doi.org/10.1038/s41598-021-86806-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jaemthaworn, Thanakorn
Kalapanulak, Saowalak
Saithong, Treenut
Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_full Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_fullStr Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_full_unstemmed Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_short Topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (CBSV) in cassava
title_sort topological clustering of regulatory genes confers pathogenic tolerance to cassava brown streak virus (cbsv) in cassava
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041763/
https://www.ncbi.nlm.nih.gov/pubmed/33846415
http://dx.doi.org/10.1038/s41598-021-86806-x
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