Cargando…

Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis

Adenosine-to-inosine (A-to-I) RNA editing catalyzed by ADAR enzymes occurs in double-stranded RNAs. Despite a compelling need towards predictive understanding of natural and engineered editing events, how the RNA sequence and structure determine the editing efficiency and specificity (i.e., cis-regu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xin, Sun, Tao, Shcherbina, Anna, Li, Qin, Jarmoskaite, Inga, Kappel, Kalli, Ramaswami, Gokul, Das, Rhiju, Kundaje, Anshul, Li, Jin Billy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041805/ https://www.ncbi.nlm.nih.gov/pubmed/33846332 http://dx.doi.org/10.1038/s41467-021-22489-2

Ejemplares similares

Genetic mapping uncovers cis-regulatory landscape of RNA editing
por: Ramaswami, Gokul, et al.
Publicado: (2015)

RADAR: a rigorously annotated database of A-to-I RNA editing
por: Ramaswami, Gokul, et al.
Publicado: (2014)

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
por: Walkley, Carl R., et al.
Publicado: (2017)

Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs
por: Vogel, Paul, et al.
Publicado: (2018)

ADAR1 Editing and its Role in Cancer
por: Xu, Li-Di, et al.
Publicado: (2018)

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
por: Kleinova, Renata, et al.
Publicado: (2023)

Promoting RNA editing by ADAR attraction
por: Danan-Gotthold, Miri, et al.
Publicado: (2017)

ADAR RNA editing below the backbone
por: Keegan, Liam, et al.
Publicado: (2017)

RNA Editing, ADAR1, and the Innate Immune Response
por: Wang, Qingde, et al.
Publicado: (2017)

ADAR Editing in Viruses: An Evolutionary Force to Reckon with
por: Piontkivska, Helen, et al.
Publicado: (2021)

RNA 3D structure prediction guided by independent folding of homologous sequences
por: Magnus, Marcin, et al.
Publicado: (2019)

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis
por: Heraud-Farlow, Jacki E., et al.
Publicado: (2017)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis
por: Parks, Joseph W., et al.
Publicado: (2017)

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila
por: Deng, Patricia, et al.
Publicado: (2020)

High-throughput mutagenesis reveals unique structural features of human ADAR1
por: Park, SeHee, et al.
Publicado: (2020)

Predicting sites of ADAR editing in double-stranded RNA
por: Eggington, Julie M., et al.
Publicado: (2011)

The origin of the ADAR gene family and animal RNA editing
por: Grice, Laura F, et al.
Publicado: (2015)

Cleavage of dsRNAs hyper-edited by ADARs occurs at preferred editing sites
por: Scadden, A. D. J., et al.
Publicado: (2005)

Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons
por: Sapiro, Anne L., et al.
Publicado: (2020)

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster
por: Li, Xianghua, et al.
Publicado: (2014)

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
por: Keegan, Liam P, et al.
Publicado: (2004)

Modulation of ADAR1 editing activity by Z-RNA in vitro
por: Koeris, Michael, et al.
Publicado: (2005)

Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR
por: Marcucci, Roberto, et al.
Publicado: (2009)

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
por: Wang, Isabel X., et al.
Publicado: (2013)

Complex regulation of ADAR-mediated RNA-editing across tissues
por: Huntley, Melanie A., et al.
Publicado: (2016)

Novel Engineered Programmable Systems for ADAR-Mediated RNA Editing
por: Aquino-Jarquin, Guillermo
Publicado: (2020)

ADAR1-Mediated RNA Editing and Its Role in Cancer
por: Liu, Jizhe, et al.
Publicado: (2022)

ADAR1-mediated RNA editing promotes B cell lymphomagenesis
por: Pecori, Riccardo, et al.
Publicado: (2023)

Brief Report: Cell Cycle Dynamics of Human Pluripotent Stem Cells Primed for Differentiation
por: Shcherbina, Anna, et al.
Publicado: (2019)

Increasing Fruit Weight by Editing a Cis-Regulatory Element in Tomato KLUH Promoter Using CRISPR/Cas9
por: Li, Qiang, et al.
Publicado: (2022)

Mutagenesis of FAD2 genes in peanut with CRISPR/Cas9 based gene editing
por: Yuan, Mei, et al.
Publicado: (2019)

Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method
por: Wang, Yuru, et al.
Publicado: (2016)

Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes
por: Liu, Huiquan, et al.
Publicado: (2016)

Editing independent effects of ADARs on the miRNA/siRNA pathways
por: Heale, Bret S E, et al.
Publicado: (2009)

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins
por: Mannion, Niamh, et al.
Publicado: (2015)

Genetic Determinants of RNA Editing Levels of ADAR Targets in Drosophila melanogaster
por: Kurmangaliyev, Yerbol Z., et al.
Publicado: (2015)

Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases
por: Song, Chunzi, et al.
Publicado: (2016)

ADAR1-mediated RNA-editing of 3′UTRs in breast cancer
por: Sagredo, Eduardo A., et al.
Publicado: (2018)

The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions
por: Zawisza-Álvarez, Michał, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_arlgg85td12vgtkph3vlvot4ks