TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7

The biological function of TRIM39, a member of TRIM family, remains largely unexplored in cancer, especially in colorectal cancer (CRC). In this study, we show that TRIM39 is upregulated in tumor tissues compared to adjacent normal tissues and associated with poor prognosis in CRC. Functional studie...

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Detalles Bibliográficos
Autores principales: Hu, Jia, Ding, Xueliang, Tian, Shaobo, Chu, Yanan, Liu, Zhibo, Li, Yuqin, Li, Xiaoqiong, Wang, Guobin, Wang, Lin, Wang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041807/
https://www.ncbi.nlm.nih.gov/pubmed/33846303
http://dx.doi.org/10.1038/s41419-021-03670-3

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