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Septal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome
Midface hypoplasia is a major manifestation of Apert syndrome. However, the tissue component responsible for midface hypoplasia has not been elucidated. We studied mice with a chondrocyte-specific Fgfr2(S252W) mutation (Col2a1-cre; Fgfr2(S252W/+)) to investigate the effect of cartilaginous component...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041873/ https://www.ncbi.nlm.nih.gov/pubmed/33846505 http://dx.doi.org/10.1038/s41598-021-87260-5 |