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An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan

The incidence of neuroendocrine tumors (NETs) has been increasing in recent decades. Previously, we reported the incidence and survival of NETs in Taiwan by analyzing the 1996–2008 data from the Taiwan Cancer Registry. Here we performed an updated analysis on the incidence and survival of NETs in Ta...

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Autores principales: Chang, Jeffrey S., Chen, Li-Tzong, Shan, Yan-Shen, Chu, Pei-Yi, Tsai, Chia-Rong, Tsai, Hui-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041887/
https://www.ncbi.nlm.nih.gov/pubmed/33846396
http://dx.doi.org/10.1038/s41598-021-86839-2
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author Chang, Jeffrey S.
Chen, Li-Tzong
Shan, Yan-Shen
Chu, Pei-Yi
Tsai, Chia-Rong
Tsai, Hui-Jen
author_facet Chang, Jeffrey S.
Chen, Li-Tzong
Shan, Yan-Shen
Chu, Pei-Yi
Tsai, Chia-Rong
Tsai, Hui-Jen
author_sort Chang, Jeffrey S.
collection PubMed
description The incidence of neuroendocrine tumors (NETs) has been increasing in recent decades. Previously, we reported the incidence and survival of NETs in Taiwan by analyzing the 1996–2008 data from the Taiwan Cancer Registry. Here we performed an updated analysis on the incidence and survival of NETs in Taiwan from 1996 to 2015. The incidence of NETs was 0.244 per 100,000 in 1996 and increased to 3.162 per 100,000 in 2015. The most common site of NETs was rectum (29.65%), followed by lung/bronchus (17.22%), and pancreas (10.71%). The 5- and 10-year overall survival rates of all NETs were 54.6% and 45.3%, respectively. Female and younger NETs patients had a better survival. The survival of all NETs diagnosed between 2010 and 2015 was better than those diagnosed between 2004 and 2009. Among the common sites of NETs, an improved survival of pancreatic NETs diagnosed between 2010 and 2015 compared to those diagnosed between 2004 and 2009 was observed. Overall, the incidence of NETs in Taiwan has continued to increase. The survival of pancreatic NET has shown a recent improvement. The development of novel therapeutic agents has the potential to improve the prognosis of NETs of other sites in the near future.
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spelling pubmed-80418872021-04-13 An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan Chang, Jeffrey S. Chen, Li-Tzong Shan, Yan-Shen Chu, Pei-Yi Tsai, Chia-Rong Tsai, Hui-Jen Sci Rep Article The incidence of neuroendocrine tumors (NETs) has been increasing in recent decades. Previously, we reported the incidence and survival of NETs in Taiwan by analyzing the 1996–2008 data from the Taiwan Cancer Registry. Here we performed an updated analysis on the incidence and survival of NETs in Taiwan from 1996 to 2015. The incidence of NETs was 0.244 per 100,000 in 1996 and increased to 3.162 per 100,000 in 2015. The most common site of NETs was rectum (29.65%), followed by lung/bronchus (17.22%), and pancreas (10.71%). The 5- and 10-year overall survival rates of all NETs were 54.6% and 45.3%, respectively. Female and younger NETs patients had a better survival. The survival of all NETs diagnosed between 2010 and 2015 was better than those diagnosed between 2004 and 2009. Among the common sites of NETs, an improved survival of pancreatic NETs diagnosed between 2010 and 2015 compared to those diagnosed between 2004 and 2009 was observed. Overall, the incidence of NETs in Taiwan has continued to increase. The survival of pancreatic NET has shown a recent improvement. The development of novel therapeutic agents has the potential to improve the prognosis of NETs of other sites in the near future. Nature Publishing Group UK 2021-04-12 /pmc/articles/PMC8041887/ /pubmed/33846396 http://dx.doi.org/10.1038/s41598-021-86839-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chang, Jeffrey S.
Chen, Li-Tzong
Shan, Yan-Shen
Chu, Pei-Yi
Tsai, Chia-Rong
Tsai, Hui-Jen
An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan
title An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan
title_full An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan
title_fullStr An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan
title_full_unstemmed An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan
title_short An updated analysis of the epidemiologic trends of neuroendocrine tumors in Taiwan
title_sort updated analysis of the epidemiologic trends of neuroendocrine tumors in taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041887/
https://www.ncbi.nlm.nih.gov/pubmed/33846396
http://dx.doi.org/10.1038/s41598-021-86839-2
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