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Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells
Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041914/ https://www.ncbi.nlm.nih.gov/pubmed/33846437 http://dx.doi.org/10.1038/s41598-021-87010-7 |
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author | Song, Xiaoxia Chen, Zhi Zhang, Xue Xiong, Junfeng Jiang, Teng Wang, Zihan Geng, Xinran Cheang, U Kei |
author_facet | Song, Xiaoxia Chen, Zhi Zhang, Xue Xiong, Junfeng Jiang, Teng Wang, Zihan Geng, Xinran Cheang, U Kei |
author_sort | Song, Xiaoxia |
collection | PubMed |
description | Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment. |
format | Online Article Text |
id | pubmed-8041914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80419142021-04-13 Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells Song, Xiaoxia Chen, Zhi Zhang, Xue Xiong, Junfeng Jiang, Teng Wang, Zihan Geng, Xinran Cheang, U Kei Sci Rep Article Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment. Nature Publishing Group UK 2021-04-12 /pmc/articles/PMC8041914/ /pubmed/33846437 http://dx.doi.org/10.1038/s41598-021-87010-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Song, Xiaoxia Chen, Zhi Zhang, Xue Xiong, Junfeng Jiang, Teng Wang, Zihan Geng, Xinran Cheang, U Kei Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells |
title | Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells |
title_full | Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells |
title_fullStr | Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells |
title_full_unstemmed | Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells |
title_short | Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells |
title_sort | magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041914/ https://www.ncbi.nlm.nih.gov/pubmed/33846437 http://dx.doi.org/10.1038/s41598-021-87010-7 |
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