Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of...

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Autores principales: Natarajan, Pradeep, Pampana, Akhil, Graham, Sarah E., Ruotsalainen, Sanni E., Perry, James A., de Vries, Paul S., Broome, Jai G., Pirruccello, James P., Honigberg, Michael C., Aragam, Krishna, Wolford, Brooke, Brody, Jennifer A., Antonacci-Fulton, Lucinda, Arden, Moscati, Aslibekyan, Stella, Assimes, Themistocles L., Ballantyne, Christie M., Bielak, Lawrence F., Bis, Joshua C., Cade, Brian E., Do, Ron, Doddapaneni, Harsha, Emery, Leslie S., Hung, Yi-Jen, Irvin, Marguerite R., Khan, Alyna T., Lange, Leslie, Lee, Jiwon, Lemaitre, Rozenn N., Martin, Lisa W., Metcalf, Ginger, Montasser, May E., Moon, Jee-Young, Muzny, Donna, O’Connell, Jeffrey R., Palmer, Nicholette D., Peralta, Juan M., Peyser, Patricia A., Stilp, Adrienne M., Tsai, Michael, Wang, Fei Fei, Weeks, Daniel E., Yanek, Lisa R., Wilson, James G., Abecasis, Goncalo, Arnett, Donna K., Becker, Lewis C., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Chang, Yi-Cheng, Chen, Yii-Der I., Choi, Won Jung, Correa, Adolfo, Curran, Joanne E., Daly, Mark J., Dutcher, Susan K., Ellinor, Patrick T., Fornage, Myriam, Freedman, Barry I., Gabriel, Stacey, Germer, Soren, Gibbs, Richard A., He, Jiang, Hveem, Kristian, Jarvik, Gail P., Kaplan, Robert C., Kardia, Sharon L. R., Kenny, Eimear, Kim, Ryan W., Kooperberg, Charles, Laurie, Cathy C., Lee, Seonwook, Lloyd-Jones, Don M., Loos, Ruth J. F., Lubitz, Steven A., Mathias, Rasika A., Martinez, Karine A. Viaud, McGarvey, Stephen T., Mitchell, Braxton D., Nickerson, Deborah A., North, Kari E., Palotie, Aarno, Park, Cheol Joo, Psaty, Bruce M., Rao, D. C., Redline, Susan, Reiner, Alexander P., Seo, Daekwan, Seo, Jeong-Sun, Smith, Albert V., Tracy, Russell P., Vasan, Ramachandran S., Kathiresan, Sekar, Cupples, L. Adrienne, Rotter, Jerome I., Morrison, Alanna C., Rich, Stephen S., Ripatti, Samuli, Willer, Cristen, Peloso, Gina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042019/
https://www.ncbi.nlm.nih.gov/pubmed/33846329
http://dx.doi.org/10.1038/s41467-021-22339-1

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