HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

The atypical antipsychotic clozapine is the only effective medication for treatment-resistant schizophrenia. However, it can also induce serious adverse drug reactions, including agranulocytosis and neutropenia. The mechanism by which it does so is largely unknown, but there is evidence for contribu...

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Detalles Bibliográficos
Autores principales: Konte, Bettina, Walters, James T. R., Rujescu, Dan, Legge, Sophie E., Pardiñas, Antonio F., Cohen, Dan, Pirmohamed, Munir, Tiihonen, Jari, Hartmann, Annette M., Bogers, Jan P., van der Weide, Jan, van der Weide, Karen, Putkonen, Anu, Repo-Tiihonen, Eila, Hallikainen, Tero, Silva, Ed, Ingimarsson, Oddur, Sigurdsson, Engilbert, Kennedy, James L., Sullivan, Patrick F., Rietschel, Marcella, Breen, Gerome, Stefansson, Hreinn, Stefansson, Kari, Collier, David A., O’Donovan, Michael C., Giegling, Ina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042025/
https://www.ncbi.nlm.nih.gov/pubmed/33846298
http://dx.doi.org/10.1038/s41398-021-01322-w

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