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Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Insufficient apoptosis of inflammatory macrophages and osteoclasts (OCs) in rheumatoid arthritis (RA) joints contributes toward the persistent progression of joint inflammation and destruction. Here, we deliver celastrol (CEL) to selectively induce apoptosis of OCs and macrophages in arthritic joint...

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Detalles Bibliográficos
Autores principales:	Deng, Caifeng, Zhang, Quan, He, Penghui, Zhou, Bin, He, Ke, Sun, Xun, Lei, Guanghua, Gong, Tao, Zhang, Zhirong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042091/ https://www.ncbi.nlm.nih.gov/pubmed/33846342 http://dx.doi.org/10.1038/s41467-021-22454-z

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