Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

Deregulation of chromatin modifiers plays an essential role in the pathogenesis of medulloblastoma, the most common paediatric malignant brain tumour. Here, we identify a BMI1-dependent sensitivity to deregulation of inositol metabolism in a proportion of medulloblastoma. We demonstrate mTOR pathway...

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Detalles Bibliográficos
Autores principales: Badodi, Sara, Pomella, Nicola, Zhang, Xinyu, Rosser, Gabriel, Whittingham, John, Niklison-Chirou, Maria Victoria, Lim, Yau Mun, Brandner, Sebastian, Morrison, Gillian, Pollard, Steven M., Bennett, Christopher D., Clifford, Steven C., Peet, Andrew, Basson, M. Albert, Marino, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042111/
https://www.ncbi.nlm.nih.gov/pubmed/33846320
http://dx.doi.org/10.1038/s41467-021-22379-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042111/
https://www.ncbi.nlm.nih.gov/pubmed/33846320
http://dx.doi.org/10.1038/s41467-021-22379-7

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