Functional cooperation between ASK1 and p21(Waf1/Cip1) in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

Both CDKN1A (p21 (Waf1/Cip1)) and Apoptosis signal-regulating kinase 1 (ASK1) play important roles in tumorigenesis. The role of p21 (Waf1/Cip1) in attenuating ASK1-induced apoptosis by various stress conditions is well established. However, how ASK1 and p21 (Waf1/Cip1) functionally interact during...

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Detalles Bibliográficos
Autores principales: De Blasio, Carlo, Verma, Nagendra, Moretti, Marta, Cialfi, Samantha, Zonfrilli, Azzurra, Franchitto, Matteo, Truglio, Federica, De Smaele, Enrico, Ichijo, Hidenori, Naguro, Isao, Screpanti, Isabella, Talora, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042117/
https://www.ncbi.nlm.nih.gov/pubmed/33846306
http://dx.doi.org/10.1038/s41420-021-00459-3

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