ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1

The acetylation of ATG9A within the endoplasmic reticulum (ER) lumen regulates the induction of reticulophagy. ER acetylation is ensured by AT-1/SLC33A1, a membrane transporter that maintains the cytosol-to-ER flux of acetyl-CoA. Defective AT-1 activity, as caused by heterozygous/homozygous mutation...

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Detalles Bibliográficos
Autores principales: Sheehan, Brendan K., Orefice, Nicola S., Peng, Yajing, Shapiro, Samantha L., Puglielli, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042170/
https://www.ncbi.nlm.nih.gov/pubmed/33870132
http://dx.doi.org/10.1016/j.isci.2021.102315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042170/
https://www.ncbi.nlm.nih.gov/pubmed/33870132
http://dx.doi.org/10.1016/j.isci.2021.102315

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