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OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination

DNA mismatch repair (MMR) maintains genome stability primarily by correcting replication errors. MMR deficiency can lead to cancer development and bolsters cancer cell resistance to chemotherapy. However, recent studies have shown that checkpoint blockade therapy is effective in MMR-deficient cancer...

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Detalles Bibliográficos
Autores principales:	Wu, Qiong, Huang, Yaping, Gu, Liya, Chang, Zhijie, Li, Guo-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042173/ https://www.ncbi.nlm.nih.gov/pubmed/33640455 http://dx.doi.org/10.1016/j.jbc.2021.100466

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