TNF receptor-associated factor 3 restrains B-cell receptor signaling in normal and malignant B cells

TRAF3 has diverse signaling functions, which vary by cell type. Uniquely in B lymphocytes, TRAF3 inhibits homeostatic survival. Highlighting the role of TRAF3 as a tumor suppressor, loss-of-function TRAF3 mutations are associated with human B-cell malignancies, while B-cell-specific deletion of TRAF...

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Detalles Bibliográficos
Autores principales: Whillock, Amy L., Ybarra, Tiffany K., Bishop, Gail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042179/
https://www.ncbi.nlm.nih.gov/pubmed/33639170
http://dx.doi.org/10.1016/j.jbc.2021.100465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042179/
https://www.ncbi.nlm.nih.gov/pubmed/33639170
http://dx.doi.org/10.1016/j.jbc.2021.100465

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