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Scalp high-frequency oscillation rates are higher in younger children

High-frequency oscillations in scalp EEG are promising non-invasive biomarkers of epileptogenicity. However, it is unclear how high-frequency oscillations are impacted by age in the paediatric population. We prospectively recorded whole-night scalp EEG in 30 children and adolescents with focal or ge...

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Autores principales: Cserpan, Dorottya, Boran, Ece, Lo Biundo, Santo Pietro, Rosch, Richard, Sarnthein, Johannes, Ramantani, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042248/
https://www.ncbi.nlm.nih.gov/pubmed/33870193
http://dx.doi.org/10.1093/braincomms/fcab052
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author Cserpan, Dorottya
Boran, Ece
Lo Biundo, Santo Pietro
Rosch, Richard
Sarnthein, Johannes
Ramantani, Georgia
author_facet Cserpan, Dorottya
Boran, Ece
Lo Biundo, Santo Pietro
Rosch, Richard
Sarnthein, Johannes
Ramantani, Georgia
author_sort Cserpan, Dorottya
collection PubMed
description High-frequency oscillations in scalp EEG are promising non-invasive biomarkers of epileptogenicity. However, it is unclear how high-frequency oscillations are impacted by age in the paediatric population. We prospectively recorded whole-night scalp EEG in 30 children and adolescents with focal or generalized epilepsy. We used an automated and clinically validated high-frequency oscillation detector to determine ripple rates (80–250 Hz) in bipolar channels. Children < 7 years had higher high-frequency oscillation rates (P = 0.021) when compared with older children. The median test−retest reliability of high-frequency oscillation rates reached 100% (iqr 50) for a data interval duration of 10 min. Scalp high-frequency oscillation frequency decreased with age (r = −0.558, P = 0.002), whereas scalp high-frequency oscillation duration and amplitude were unaffected. The signal-to-noise ratio improved with age (r = 0.37, P = 0.048), and the background ripple band activity decreased with age (r = −0.463, P = 0.011). We characterize the relationship of scalp high-frequency oscillation features and age in paediatric patients. EEG intervals of [Formula: see text] 10 min duration are required for reliable measurements of high-frequency oscillation rates. This study is a further step towards establishing scalp high-frequency oscillations as a valid epileptogenicity biomarker in this vulnerable age group.
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spelling pubmed-80422482021-04-16 Scalp high-frequency oscillation rates are higher in younger children Cserpan, Dorottya Boran, Ece Lo Biundo, Santo Pietro Rosch, Richard Sarnthein, Johannes Ramantani, Georgia Brain Commun Original Article High-frequency oscillations in scalp EEG are promising non-invasive biomarkers of epileptogenicity. However, it is unclear how high-frequency oscillations are impacted by age in the paediatric population. We prospectively recorded whole-night scalp EEG in 30 children and adolescents with focal or generalized epilepsy. We used an automated and clinically validated high-frequency oscillation detector to determine ripple rates (80–250 Hz) in bipolar channels. Children < 7 years had higher high-frequency oscillation rates (P = 0.021) when compared with older children. The median test−retest reliability of high-frequency oscillation rates reached 100% (iqr 50) for a data interval duration of 10 min. Scalp high-frequency oscillation frequency decreased with age (r = −0.558, P = 0.002), whereas scalp high-frequency oscillation duration and amplitude were unaffected. The signal-to-noise ratio improved with age (r = 0.37, P = 0.048), and the background ripple band activity decreased with age (r = −0.463, P = 0.011). We characterize the relationship of scalp high-frequency oscillation features and age in paediatric patients. EEG intervals of [Formula: see text] 10 min duration are required for reliable measurements of high-frequency oscillation rates. This study is a further step towards establishing scalp high-frequency oscillations as a valid epileptogenicity biomarker in this vulnerable age group. Oxford University Press 2021-03-23 /pmc/articles/PMC8042248/ /pubmed/33870193 http://dx.doi.org/10.1093/braincomms/fcab052 Text en © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cserpan, Dorottya
Boran, Ece
Lo Biundo, Santo Pietro
Rosch, Richard
Sarnthein, Johannes
Ramantani, Georgia
Scalp high-frequency oscillation rates are higher in younger children
title Scalp high-frequency oscillation rates are higher in younger children
title_full Scalp high-frequency oscillation rates are higher in younger children
title_fullStr Scalp high-frequency oscillation rates are higher in younger children
title_full_unstemmed Scalp high-frequency oscillation rates are higher in younger children
title_short Scalp high-frequency oscillation rates are higher in younger children
title_sort scalp high-frequency oscillation rates are higher in younger children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042248/
https://www.ncbi.nlm.nih.gov/pubmed/33870193
http://dx.doi.org/10.1093/braincomms/fcab052
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