Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists

Nociceptin/orphanin FQ controls several functions, including pain transmission, via stimulation of the N/OFQ peptide (NOP) receptor. Here we tested the hypothesis that NOP biased agonism may be instrumental for identifying innovative analgesics. In vitro experiments were performed with the dynamic m...

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Detalles Bibliográficos
Autores principales: Azevedo Neto, Joaquim, Ruzza, Chiara, Sturaro, Chiara, Malfacini, Davide, Pacifico, Salvatore, Zaveri, Nurulain T., Calò, Girolamo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042269/
https://www.ncbi.nlm.nih.gov/pubmed/33859548
http://dx.doi.org/10.3389/fnins.2021.657153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042269/
https://www.ncbi.nlm.nih.gov/pubmed/33859548
http://dx.doi.org/10.3389/fnins.2021.657153

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