Airway Epithelial Inflammation In Vitro Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies

In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. The most common CFTR mutation, F508del, results in a pr...

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Detalles Bibliográficos
Autores principales: Gentzsch, Martina, Cholon, Deborah M., Quinney, Nancy L., Martino, Mary E. B., Minges, John T., Boyles, Susan E., Guhr Lee, Tara N., Esther, Charles R., Ribeiro, Carla M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042279/
https://www.ncbi.nlm.nih.gov/pubmed/33859562
http://dx.doi.org/10.3389/fphar.2021.628722

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