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Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for ce...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korea Genome Organization
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042306/ https://www.ncbi.nlm.nih.gov/pubmed/33840169 http://dx.doi.org/10.5808/gi.20065 |
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author | Aditya, Jain Smiline Girija, A. S. Paramasivam, A. Vijayashree Priyadharsini, J. |
author_facet | Aditya, Jain Smiline Girija, A. S. Paramasivam, A. Vijayashree Priyadharsini, J. |
author_sort | Aditya, Jain |
collection | PubMed |
description | Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. The present study aims to assess the gene alterations in the Wnt family of genes so as to derive an association with HNSCC. Computational approaches have been utilized for the identification of gene alterations in the Wnt family of genes. Several databases such as cBioportal, STRING, and UALCAN were used for the purpose. The frequency of alteration was high in case of Wnt family member 11 (5%). Gene amplification, deep deletions, missense and truncating mutations were observed in HNSCC patients. There was a marked difference in the gene expression profile of WNT11 between grades as well as normal samples. The survival probability measured using the Kaplan-Meier curve also presented with a significant difference among male and female subjects experiencing a low/medium level expression. The female patients showed less survival probability when compared to the male subjects. This provides the prognostic significance of the WNT11 gene in HNSCC. Taken together, the present study provides clues on the possible association of WNT11 gene alterations with HNSCC, which has to be further validated using experimental approaches. |
format | Online Article Text |
id | pubmed-8042306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korea Genome Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-80423062021-04-19 Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma Aditya, Jain Smiline Girija, A. S. Paramasivam, A. Vijayashree Priyadharsini, J. Genomics Inform Original Article Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. The present study aims to assess the gene alterations in the Wnt family of genes so as to derive an association with HNSCC. Computational approaches have been utilized for the identification of gene alterations in the Wnt family of genes. Several databases such as cBioportal, STRING, and UALCAN were used for the purpose. The frequency of alteration was high in case of Wnt family member 11 (5%). Gene amplification, deep deletions, missense and truncating mutations were observed in HNSCC patients. There was a marked difference in the gene expression profile of WNT11 between grades as well as normal samples. The survival probability measured using the Kaplan-Meier curve also presented with a significant difference among male and female subjects experiencing a low/medium level expression. The female patients showed less survival probability when compared to the male subjects. This provides the prognostic significance of the WNT11 gene in HNSCC. Taken together, the present study provides clues on the possible association of WNT11 gene alterations with HNSCC, which has to be further validated using experimental approaches. Korea Genome Organization 2021-03-26 /pmc/articles/PMC8042306/ /pubmed/33840169 http://dx.doi.org/10.5808/gi.20065 Text en (c) 2021, Korea Genome Organization https://creativecommons.org/licenses/by/4.0/(CC) This is an open-access article distributed under the terms of the Creative Commons Attribution license(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Aditya, Jain Smiline Girija, A. S. Paramasivam, A. Vijayashree Priyadharsini, J. Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma |
title | Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma |
title_full | Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma |
title_fullStr | Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma |
title_full_unstemmed | Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma |
title_short | Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma |
title_sort | genetic alterations in wnt family of genes and their putative association with head and neck squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042306/ https://www.ncbi.nlm.nih.gov/pubmed/33840169 http://dx.doi.org/10.5808/gi.20065 |
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