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Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model

Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a small subset of patients, partly because of the lack of sufficient immune cells in the tumor. It is reported that targeted lactate dehydrogenase (LDH) to reduce lactic acid production can promote the infilt...

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Detalles Bibliográficos
Autores principales:	Qiao, Tianyun, Xiong, Yanlu, Feng, Yangbo, Guo, Wenwen, Zhou, Yongsheng, Zhao, Jinbo, Jiang, Tao, Shi, Changhong, Han, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042335/ https://www.ncbi.nlm.nih.gov/pubmed/33859941 http://dx.doi.org/10.3389/fonc.2021.632364

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