Cargando…
Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil
Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042373/ https://www.ncbi.nlm.nih.gov/pubmed/33859996 http://dx.doi.org/10.3389/fmolb.2021.627817 |
_version_ | 1783678113916387328 |
---|---|
author | Zhang, Zheng Yang, Jun Yang, Qing Tian, Guangyong Cui, Zhong-Kai |
author_facet | Zhang, Zheng Yang, Jun Yang, Qing Tian, Guangyong Cui, Zhong-Kai |
author_sort | Zhang, Zheng |
collection | PubMed |
description | Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non-phospholipid liposomes (sterosomes) as a pesticide nanocarrier, and were characterized with field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) spectrometer, size distribution, and ζ-potential. The results showed sterosomes were successfully loaded with cymoxanil. The loading efficiency and the drug-to-lipid ratio were 92.6% and 0.0761, respectively. Prolonged drug release was obtained for 3 days, improving the short duration of the drug itself. The addition of cymoxanil-loaded sterosomes in culture medium effectively inhibited the growth of yeast cells, which serve as model fungal targets. Sterosomes as nanocarriers significantly improved the stability and efficacy of cymoxanil, thus introducing practical and economically desirable strategies for the preparation of novel pesticide formulations. |
format | Online Article Text |
id | pubmed-8042373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80423732021-04-14 Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil Zhang, Zheng Yang, Jun Yang, Qing Tian, Guangyong Cui, Zhong-Kai Front Mol Biosci Molecular Biosciences Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non-phospholipid liposomes (sterosomes) as a pesticide nanocarrier, and were characterized with field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) spectrometer, size distribution, and ζ-potential. The results showed sterosomes were successfully loaded with cymoxanil. The loading efficiency and the drug-to-lipid ratio were 92.6% and 0.0761, respectively. Prolonged drug release was obtained for 3 days, improving the short duration of the drug itself. The addition of cymoxanil-loaded sterosomes in culture medium effectively inhibited the growth of yeast cells, which serve as model fungal targets. Sterosomes as nanocarriers significantly improved the stability and efficacy of cymoxanil, thus introducing practical and economically desirable strategies for the preparation of novel pesticide formulations. Frontiers Media S.A. 2021-03-30 /pmc/articles/PMC8042373/ /pubmed/33859996 http://dx.doi.org/10.3389/fmolb.2021.627817 Text en Copyright © 2021 Zhang, Yang, Yang, Tian and Cui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Zhang, Zheng Yang, Jun Yang, Qing Tian, Guangyong Cui, Zhong-Kai Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
title | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
title_full | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
title_fullStr | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
title_full_unstemmed | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
title_short | Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil |
title_sort | fabrication of non-phospholipid liposomal nanocarrier for sustained-release of the fungicide cymoxanil |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042373/ https://www.ncbi.nlm.nih.gov/pubmed/33859996 http://dx.doi.org/10.3389/fmolb.2021.627817 |
work_keys_str_mv | AT zhangzheng fabricationofnonphospholipidliposomalnanocarrierforsustainedreleaseofthefungicidecymoxanil AT yangjun fabricationofnonphospholipidliposomalnanocarrierforsustainedreleaseofthefungicidecymoxanil AT yangqing fabricationofnonphospholipidliposomalnanocarrierforsustainedreleaseofthefungicidecymoxanil AT tianguangyong fabricationofnonphospholipidliposomalnanocarrierforsustainedreleaseofthefungicidecymoxanil AT cuizhongkai fabricationofnonphospholipidliposomalnanocarrierforsustainedreleaseofthefungicidecymoxanil |