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Association Between Longitudinal Change in Abnormal Fasting Blood Glucose Levels and Outcome of COVID-19 Patients Without Previous Diagnosis of Diabetes

This retrospective study examined changes in fasting blood glucose (FBG) levels during hospitalization and their effect on risk of death for Coronavirus disease 2019 (COVID-19) patients without previously diagnosed diabetes. A model with low- and high-stable pattern trajectories was established base...

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Autores principales: Song, Siwei, Zhang, Shujing, Wang, Zhihui, Wang, Sufei, Ma, Yanling, Ma, Pei, Luo, Huilin, Wang, Mengyuan, Jin, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042381/
https://www.ncbi.nlm.nih.gov/pubmed/33859617
http://dx.doi.org/10.3389/fendo.2021.640529
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author Song, Siwei
Zhang, Shujing
Wang, Zhihui
Wang, Sufei
Ma, Yanling
Ma, Pei
Luo, Huilin
Wang, Mengyuan
Jin, Yang
author_facet Song, Siwei
Zhang, Shujing
Wang, Zhihui
Wang, Sufei
Ma, Yanling
Ma, Pei
Luo, Huilin
Wang, Mengyuan
Jin, Yang
author_sort Song, Siwei
collection PubMed
description This retrospective study examined changes in fasting blood glucose (FBG) levels during hospitalization and their effect on risk of death for Coronavirus disease 2019 (COVID-19) patients without previously diagnosed diabetes. A model with low- and high-stable pattern trajectories was established based on a longitudinal change in FBG levels. We analyzed FBG trajectory-associated clinical features and risk factors for death due to COVID-19. Of the 230 enrolled patients, 44 died and 87.83% had a low-stable pattern (average FBG range: 6.63–7.54 mmol/L), and 12.17% had a high-stable pattern (average FBG range: 12.59–14.02 mmol/L). There were statistical differences in laboratory findings and case fatality between the two FBG patterns. Multivariable logistic regression analysis showed that increased neutrophil count (odds ratio [OR], 25.43; 95% confidence interval [CI]: 2.07, 313.03), elevated direct bilirubin (OR, 5.80; 95%CI: 1.72, 19.58), elevated creatinine (OR, 26.69; 95% CI: 5.82, 122.29), lymphopenia (OR, 8.07; 95% CI: 2.70, 24.14), and high-stable FBG pattern (OR, 8.79; 95% CI: 2.39, 32.29) were independent risk factors for higher case fatality in patients with COVID-19 and hyperglycemia but no history of diabetes. FBG trajectories were significantly associated with death risk in patients with COVID-19 and no diabetes.
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spelling pubmed-80423812021-04-14 Association Between Longitudinal Change in Abnormal Fasting Blood Glucose Levels and Outcome of COVID-19 Patients Without Previous Diagnosis of Diabetes Song, Siwei Zhang, Shujing Wang, Zhihui Wang, Sufei Ma, Yanling Ma, Pei Luo, Huilin Wang, Mengyuan Jin, Yang Front Endocrinol (Lausanne) Endocrinology This retrospective study examined changes in fasting blood glucose (FBG) levels during hospitalization and their effect on risk of death for Coronavirus disease 2019 (COVID-19) patients without previously diagnosed diabetes. A model with low- and high-stable pattern trajectories was established based on a longitudinal change in FBG levels. We analyzed FBG trajectory-associated clinical features and risk factors for death due to COVID-19. Of the 230 enrolled patients, 44 died and 87.83% had a low-stable pattern (average FBG range: 6.63–7.54 mmol/L), and 12.17% had a high-stable pattern (average FBG range: 12.59–14.02 mmol/L). There were statistical differences in laboratory findings and case fatality between the two FBG patterns. Multivariable logistic regression analysis showed that increased neutrophil count (odds ratio [OR], 25.43; 95% confidence interval [CI]: 2.07, 313.03), elevated direct bilirubin (OR, 5.80; 95%CI: 1.72, 19.58), elevated creatinine (OR, 26.69; 95% CI: 5.82, 122.29), lymphopenia (OR, 8.07; 95% CI: 2.70, 24.14), and high-stable FBG pattern (OR, 8.79; 95% CI: 2.39, 32.29) were independent risk factors for higher case fatality in patients with COVID-19 and hyperglycemia but no history of diabetes. FBG trajectories were significantly associated with death risk in patients with COVID-19 and no diabetes. Frontiers Media S.A. 2021-03-30 /pmc/articles/PMC8042381/ /pubmed/33859617 http://dx.doi.org/10.3389/fendo.2021.640529 Text en Copyright © 2021 Song, Zhang, Wang, Wang, Ma, Ma, Luo, Wang and Jin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Song, Siwei
Zhang, Shujing
Wang, Zhihui
Wang, Sufei
Ma, Yanling
Ma, Pei
Luo, Huilin
Wang, Mengyuan
Jin, Yang
Association Between Longitudinal Change in Abnormal Fasting Blood Glucose Levels and Outcome of COVID-19 Patients Without Previous Diagnosis of Diabetes
title Association Between Longitudinal Change in Abnormal Fasting Blood Glucose Levels and Outcome of COVID-19 Patients Without Previous Diagnosis of Diabetes
title_full Association Between Longitudinal Change in Abnormal Fasting Blood Glucose Levels and Outcome of COVID-19 Patients Without Previous Diagnosis of Diabetes
title_fullStr Association Between Longitudinal Change in Abnormal Fasting Blood Glucose Levels and Outcome of COVID-19 Patients Without Previous Diagnosis of Diabetes
title_full_unstemmed Association Between Longitudinal Change in Abnormal Fasting Blood Glucose Levels and Outcome of COVID-19 Patients Without Previous Diagnosis of Diabetes
title_short Association Between Longitudinal Change in Abnormal Fasting Blood Glucose Levels and Outcome of COVID-19 Patients Without Previous Diagnosis of Diabetes
title_sort association between longitudinal change in abnormal fasting blood glucose levels and outcome of covid-19 patients without previous diagnosis of diabetes
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042381/
https://www.ncbi.nlm.nih.gov/pubmed/33859617
http://dx.doi.org/10.3389/fendo.2021.640529
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