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A Cas9–transcription factor fusion protein enhances homology-directed repair efficiency

Precise gene insertion or replacement in cells and animals that requires incorporation of a foreign DNA template into the genome target site by homology-directed repair (HDR) remains an inefficient process. One of the limiting factors for the inefficiency of HDR lies in the limited chance for coloca...

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Detalles Bibliográficos
Autores principales:	Li, Guoling, Wang, Haoqiang, Zhang, Xianwei, Wu, Zhenfang, Yang, Huaqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042446/ https://www.ncbi.nlm.nih.gov/pubmed/33689695 http://dx.doi.org/10.1016/j.jbc.2021.100525

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