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SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function

SLCO1B1 (solute carrier organic anion transporter family member 1B1) is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding, resulting in protein degradation and decreased transporter activity. Next-generation...

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Detalles Bibliográficos
Autores principales:	Zhang, Lingxin, Sarangi, Vivekananda, Ho, Ming-Fen, Moon, Irene, Kalari, Krishna R., Wang, Liewei, Weinshilboum, Richard M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042483/ https://www.ncbi.nlm.nih.gov/pubmed/33658230 http://dx.doi.org/10.1124/dmd.120.000264

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