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Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression

Mitotic entry involves inhibition of protein phosphatase 2A bound to its B55/Tws regulatory subunit (PP2A-B55/Tws), which dephosphorylates substrates of mitotic kinases. This inhibition is induced when Greatwall phosphorylates Endos, turning it into an inhibitor of PP2A-Tws. How this mechanism opera...

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Detalles Bibliográficos
Autores principales:	Larouche, Myreille, Kachaner, David, Wang, Peng, Normandin, Karine, Garrido, Damien, Yao, Changfu, Cormier, Maxime, Johansen, Kristen M., Johansen, Jørgen, Archambault, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042607/ https://www.ncbi.nlm.nih.gov/pubmed/33836042 http://dx.doi.org/10.1083/jcb.202008145

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