Trop‐2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis

Trop-2 is a transmembrane signal transducer that can induce cancer growth. Using antibody targeting and N-terminal Edman degradation, we show here that Trop-2 undergoes cleavage in the first thyroglobulin domain loop of its extracellular region, between residues R87 and T88. Molecular modeling indic...

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Detalles Bibliográficos
Autores principales: Trerotola, Marco, Guerra, Emanuela, Ali, Zeeshan, Aloisi, Anna Laura, Ceci, Martina, Simeone, Pasquale, Acciarito, Angela, Zanna, Paola, Vacca, Giovanna, D'Amore, Antonella, Boujnah, Khouloud, Garbo, Valeria, Moschella, Antonino, Lattanzio, Rossano, Alberti, Saverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042651/
https://www.ncbi.nlm.nih.gov/pubmed/33839455
http://dx.doi.org/10.1016/j.neo.2021.03.006

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