Radiation-Induced Vascular Disease—A State-of-the-Art Review

Since the 1990s, there has been a steady increase in the number of cancer survivors to an estimated 17 million in 2019 in the US alone. Radiation therapy today is applied to a variety of malignancies and over 50% of cancer patients. The effects of ionizing radiation on cardiac structure and function...

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Autores principales: Yang, Eric H., Marmagkiolis, Konstantinos, Balanescu, Dinu V., Hakeem, Abdul, Donisan, Teodora, Finch, William, Virmani, Renu, Herrman, Joerg, Cilingiroglu, Mehmet, Grines, Cindy L., Toutouzas, Konstantinos, Iliescu, Cezar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042773/
https://www.ncbi.nlm.nih.gov/pubmed/33860001
http://dx.doi.org/10.3389/fcvm.2021.652761
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author Yang, Eric H.
Marmagkiolis, Konstantinos
Balanescu, Dinu V.
Hakeem, Abdul
Donisan, Teodora
Finch, William
Virmani, Renu
Herrman, Joerg
Cilingiroglu, Mehmet
Grines, Cindy L.
Toutouzas, Konstantinos
Iliescu, Cezar
author_facet Yang, Eric H.
Marmagkiolis, Konstantinos
Balanescu, Dinu V.
Hakeem, Abdul
Donisan, Teodora
Finch, William
Virmani, Renu
Herrman, Joerg
Cilingiroglu, Mehmet
Grines, Cindy L.
Toutouzas, Konstantinos
Iliescu, Cezar
author_sort Yang, Eric H.
collection PubMed
description Since the 1990s, there has been a steady increase in the number of cancer survivors to an estimated 17 million in 2019 in the US alone. Radiation therapy today is applied to a variety of malignancies and over 50% of cancer patients. The effects of ionizing radiation on cardiac structure and function, so-called radiation-induced heart disease (RIHD), have been extensively studied. We review the available published data on the mechanisms and manifestations of RIHD, with a focus on vascular disease, as well as proposed strategies for its prevention, screening, diagnosis, and management.
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spelling pubmed-80427732021-04-14 Radiation-Induced Vascular Disease—A State-of-the-Art Review Yang, Eric H. Marmagkiolis, Konstantinos Balanescu, Dinu V. Hakeem, Abdul Donisan, Teodora Finch, William Virmani, Renu Herrman, Joerg Cilingiroglu, Mehmet Grines, Cindy L. Toutouzas, Konstantinos Iliescu, Cezar Front Cardiovasc Med Cardiovascular Medicine Since the 1990s, there has been a steady increase in the number of cancer survivors to an estimated 17 million in 2019 in the US alone. Radiation therapy today is applied to a variety of malignancies and over 50% of cancer patients. The effects of ionizing radiation on cardiac structure and function, so-called radiation-induced heart disease (RIHD), have been extensively studied. We review the available published data on the mechanisms and manifestations of RIHD, with a focus on vascular disease, as well as proposed strategies for its prevention, screening, diagnosis, and management. Frontiers Media S.A. 2021-03-30 /pmc/articles/PMC8042773/ /pubmed/33860001 http://dx.doi.org/10.3389/fcvm.2021.652761 Text en Copyright © 2021 Yang, Marmagkiolis, Balanescu, Hakeem, Donisan, Finch, Virmani, Herrman, Cilingiroglu, Grines, Toutouzas and Iliescu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Yang, Eric H.
Marmagkiolis, Konstantinos
Balanescu, Dinu V.
Hakeem, Abdul
Donisan, Teodora
Finch, William
Virmani, Renu
Herrman, Joerg
Cilingiroglu, Mehmet
Grines, Cindy L.
Toutouzas, Konstantinos
Iliescu, Cezar
Radiation-Induced Vascular Disease—A State-of-the-Art Review
title Radiation-Induced Vascular Disease—A State-of-the-Art Review
title_full Radiation-Induced Vascular Disease—A State-of-the-Art Review
title_fullStr Radiation-Induced Vascular Disease—A State-of-the-Art Review
title_full_unstemmed Radiation-Induced Vascular Disease—A State-of-the-Art Review
title_short Radiation-Induced Vascular Disease—A State-of-the-Art Review
title_sort radiation-induced vascular disease—a state-of-the-art review
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042773/
https://www.ncbi.nlm.nih.gov/pubmed/33860001
http://dx.doi.org/10.3389/fcvm.2021.652761
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