Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action

Proteins represent the major building blocks of body tissues, and they regulate signaling involved in most cellular activities. Coronavirus disease 2019 (COVID-19) infection has been associated with high fatality, especially among older adults. The main cause of death is pulmonary tissue damage and...

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Autores principales: Ali, Amira Mohammed, Kunugi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042835/
https://www.ncbi.nlm.nih.gov/pubmed/33849598
http://dx.doi.org/10.1186/s13000-021-01092-5
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author Ali, Amira Mohammed
Kunugi, Hiroshi
author_facet Ali, Amira Mohammed
Kunugi, Hiroshi
author_sort Ali, Amira Mohammed
collection PubMed
description Proteins represent the major building blocks of body tissues, and they regulate signaling involved in most cellular activities. Coronavirus disease 2019 (COVID-19) infection has been associated with high fatality, especially among older adults. The main cause of death is pulmonary tissue damage and multiple organ failure. The disease is associated with a hypercatabolic state that entails excessive protein loss. This review commentary sheds the light on hypoproteinemia in symptomatic/hospitalized COVID-19 with a special emphasis on its pathophysiology, screening, as well as its contribution to disease severity and adverse effects.
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spelling pubmed-80428352021-04-13 Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action Ali, Amira Mohammed Kunugi, Hiroshi Diagn Pathol Commentary Proteins represent the major building blocks of body tissues, and they regulate signaling involved in most cellular activities. Coronavirus disease 2019 (COVID-19) infection has been associated with high fatality, especially among older adults. The main cause of death is pulmonary tissue damage and multiple organ failure. The disease is associated with a hypercatabolic state that entails excessive protein loss. This review commentary sheds the light on hypoproteinemia in symptomatic/hospitalized COVID-19 with a special emphasis on its pathophysiology, screening, as well as its contribution to disease severity and adverse effects. BioMed Central 2021-04-13 /pmc/articles/PMC8042835/ /pubmed/33849598 http://dx.doi.org/10.1186/s13000-021-01092-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Ali, Amira Mohammed
Kunugi, Hiroshi
Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action
title Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action
title_full Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action
title_fullStr Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action
title_full_unstemmed Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action
title_short Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action
title_sort hypoproteinemia predicts disease severity and mortality in covid-19: a call for action
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042835/
https://www.ncbi.nlm.nih.gov/pubmed/33849598
http://dx.doi.org/10.1186/s13000-021-01092-5
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