Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China

BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide. In this study, we aimed to explore whether some genetic variants of the human IDOL gene were associated with CAD among Chinese population in Xinjiang. METHODS: We designed two independent case–control studies. The fir...

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Autores principales: Adi, Dilare, Abuzhalihan, Jialin, Tao, Jing, Wu, Yun, Wang, Ying-Hong, Liu, Fen, Yang, Yi-Ning, Ma, Xiang, Li, Xiao-Mei, Xie, Xiang, Fu, Zhen-Yan, Ma, Yi-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042894/
https://www.ncbi.nlm.nih.gov/pubmed/33845890
http://dx.doi.org/10.1186/s41065-021-00178-w
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author Adi, Dilare
Abuzhalihan, Jialin
Tao, Jing
Wu, Yun
Wang, Ying-Hong
Liu, Fen
Yang, Yi-Ning
Ma, Xiang
Li, Xiao-Mei
Xie, Xiang
Fu, Zhen-Yan
Ma, Yi-Tong
author_facet Adi, Dilare
Abuzhalihan, Jialin
Tao, Jing
Wu, Yun
Wang, Ying-Hong
Liu, Fen
Yang, Yi-Ning
Ma, Xiang
Li, Xiao-Mei
Xie, Xiang
Fu, Zhen-Yan
Ma, Yi-Tong
author_sort Adi, Dilare
collection PubMed
description BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide. In this study, we aimed to explore whether some genetic variants of the human IDOL gene were associated with CAD among Chinese population in Xinjiang. METHODS: We designed two independent case–control studies. The first one included in the Han population (448 CAD patients and 343 controls), and the second one is the Uygur population (304 CAD patients and 318 controls). We genotyped three SNPs (rs2072783, rs2205796, and rs909562) of the IDOL gene. RESULTS: Our results revealed that, in the Han female subjects, for rs2205796, the distribution of alleles, dominant model (TT vs. GG + GT) and the additive model (GG + TT vs. GT) showed significant differences between CAD patients and the control subjects (P = 0.048, P = 0.014, and P = 0.032, respectively). CONCLUSIONS: The rs2205796 polymorphism of the IDOL gene is associated with CAD in the Chinese Han female population in Xinjiang, China.
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spelling pubmed-80428942021-04-14 Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China Adi, Dilare Abuzhalihan, Jialin Tao, Jing Wu, Yun Wang, Ying-Hong Liu, Fen Yang, Yi-Ning Ma, Xiang Li, Xiao-Mei Xie, Xiang Fu, Zhen-Yan Ma, Yi-Tong Hereditas Research BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide. In this study, we aimed to explore whether some genetic variants of the human IDOL gene were associated with CAD among Chinese population in Xinjiang. METHODS: We designed two independent case–control studies. The first one included in the Han population (448 CAD patients and 343 controls), and the second one is the Uygur population (304 CAD patients and 318 controls). We genotyped three SNPs (rs2072783, rs2205796, and rs909562) of the IDOL gene. RESULTS: Our results revealed that, in the Han female subjects, for rs2205796, the distribution of alleles, dominant model (TT vs. GG + GT) and the additive model (GG + TT vs. GT) showed significant differences between CAD patients and the control subjects (P = 0.048, P = 0.014, and P = 0.032, respectively). CONCLUSIONS: The rs2205796 polymorphism of the IDOL gene is associated with CAD in the Chinese Han female population in Xinjiang, China. BioMed Central 2021-04-12 /pmc/articles/PMC8042894/ /pubmed/33845890 http://dx.doi.org/10.1186/s41065-021-00178-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Adi, Dilare
Abuzhalihan, Jialin
Tao, Jing
Wu, Yun
Wang, Ying-Hong
Liu, Fen
Yang, Yi-Ning
Ma, Xiang
Li, Xiao-Mei
Xie, Xiang
Fu, Zhen-Yan
Ma, Yi-Tong
Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
title Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
title_full Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
title_fullStr Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
title_full_unstemmed Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
title_short Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China
title_sort genetic polymorphism of idol gene was associated with the susceptibility of coronary artery disease in han population in xinjiang, china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042894/
https://www.ncbi.nlm.nih.gov/pubmed/33845890
http://dx.doi.org/10.1186/s41065-021-00178-w
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