H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?

Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H(1)-receptor antagonist are common drugs used in mild/moderat...

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Autores principales: Borro, Matteo, Negrini, Simone, Long, Andrew, Chinthrajah, Sharon, Murdaca, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042967/
https://www.ncbi.nlm.nih.gov/pubmed/33849573
http://dx.doi.org/10.1186/s12948-021-00143-y
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author Borro, Matteo
Negrini, Simone
Long, Andrew
Chinthrajah, Sharon
Murdaca, Giuseppe
author_facet Borro, Matteo
Negrini, Simone
Long, Andrew
Chinthrajah, Sharon
Murdaca, Giuseppe
author_sort Borro, Matteo
collection PubMed
description Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H(1)-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H(2)-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H(1)-antagonists. The purpose of this article is to produce a complete summary of findings and evidence known so far about the usefulness of H(2)-receptor antagonist in allergic reactons.
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spelling pubmed-80429672021-04-14 H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far? Borro, Matteo Negrini, Simone Long, Andrew Chinthrajah, Sharon Murdaca, Giuseppe Clin Mol Allergy Letters to the Editor Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H(1)-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H(2)-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H(1)-antagonists. The purpose of this article is to produce a complete summary of findings and evidence known so far about the usefulness of H(2)-receptor antagonist in allergic reactons. BioMed Central 2021-04-13 /pmc/articles/PMC8042967/ /pubmed/33849573 http://dx.doi.org/10.1186/s12948-021-00143-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letters to the Editor
Borro, Matteo
Negrini, Simone
Long, Andrew
Chinthrajah, Sharon
Murdaca, Giuseppe
H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?
title H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?
title_full H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?
title_fullStr H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?
title_full_unstemmed H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?
title_short H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?
title_sort h2-antagonist in ige-mediated type i hypersensitivity reactions: what literature says so far?
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042967/
https://www.ncbi.nlm.nih.gov/pubmed/33849573
http://dx.doi.org/10.1186/s12948-021-00143-y
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